Identification of a T Cell Hybridoma which Produces Extraordinary Quantities of Macrophage Activating Factor
It is now generally accepted that under certain conditions the macrophage can express effector cell function toward a variety of neoplastic cells (1,2). Current evidence indicates that the macrophage tumoricidal response is initiated and/or augmented by a T cell product, denoted as macrophage activating factor or MAF (3–7). MAF is thought to alter or “prime” the macrophage in such a way as to make it responsive to a second or “triggering” signal which ultimately activates the tumoricidal potential of the cell (8–12).
KeywordsMigration Inhibition Factor Constitutive Product Extraordinary Quantity Scripps Clinic Biochemical Purification
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- 2.Keller, R., Lymphokines 3:283, 1981.Google Scholar
- 10.Meltzer, M. S., Lymphokines 3:319, 1981.Google Scholar
- 12.Schreiber, R. D., Ziegler, H. K., Calamai, E., and Unanue, E. R., Fed. Proc. 40:1002, 1981.Google Scholar
- 14.Altman, A., Sferruzza, A., Weiner, R. G., and Katz, D. H., J. Immunol. 128, 1982, in press.Google Scholar