Identification of a T Cell Hybridoma which Produces Extraordinary Quantities of Macrophage Activating Factor

  • Robert D. Schreiber
  • Amnon Altman
  • David H. Katz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


It is now generally accepted that under certain conditions the macrophage can express effector cell function toward a variety of neoplastic cells (1,2). Current evidence indicates that the macrophage tumoricidal response is initiated and/or augmented by a T cell product, denoted as macrophage activating factor or MAF (3–7). MAF is thought to alter or “prime” the macrophage in such a way as to make it responsive to a second or “triggering” signal which ultimately activates the tumoricidal potential of the cell (8–12).


Migration Inhibition Factor Constitutive Product Extraordinary Quantity Scripps Clinic Biochemical Purification 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Robert D. Schreiber
    • 1
  • Amnon Altman
    • 1
  • David H. Katz
    • 1
  1. 1.Department of Molecular ImmunologyResearch Institute of Scripps ClinicLa JollaUSA

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