Advertisement

Activation of Tumoricidal and/or Suppressor Macrophages: Different Stimulatory Signals Trigger Either Function both in Vivo and In Vitro

  • D. Taramelli
  • M. B. Bagley
  • H. T. Holden
  • L. Varesio
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)

Abstract

Macrophages upon in vivo and in vitro stimulation become activated and manifest functional and morphological characteristics either not present or differently expressed in non-stimulated macrophage populations (1–4). Antithetical functions can be exerted by a given macrophage population. For instance, cytotoxic macrophages could contribute to the elimination of infectious agents or to the control of neoplastic growth. On the other hand, by inhibiting certain immune responses, suppressor macrophages could impair host defense mechanisms.

Keywords

Migration Inhibitory Factor None None Macrophage Population 51Cr Release Tumor Cytotoxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Mononuclear Phagocytes (R. van Furth, ed.), Martinus Nijhoff Publishers, The Hague, Vol. I–II, 1980.Google Scholar
  2. 2.
    Oehler, J. R., Herberman, R. B., and Holden, H. T., Pharmac. Ther. A. 2:551, 1978.Google Scholar
  3. 3.
    Varesio, L., and Holden, H. T., J. Immunol. 125:1694, 1980.PubMedGoogle Scholar
  4. 4.
    Varesio, L., Holden, H. T., and Taramelli, D., Cell. Immunol. 63:279, 1981.PubMedCrossRefGoogle Scholar
  5. 5.
    David, J. R., Remold, H. G., in “Biology of Lymphokines” (S. Cohen, E. Pick, J. J. Oppenheim, eds.), pp. 121–140, Academic Press, New York, 1979.Google Scholar
  6. 6.
    Taramelli, D., and Varesio, L., J. Immunol. 127:58, 1981.PubMedGoogle Scholar
  7. 7.
    Taramelli, D., Holden, H. T., and Varesio, L., J. Immunol. Methods 37:225, 1980.PubMedCrossRefGoogle Scholar
  8. 8.
    Varesio, L., and Holden, H. T., Cell. Immunol. 56:16, 1980.PubMedCrossRefGoogle Scholar
  9. 9.
    Taramelli, D., Holden, H. T., and Varesio, L., J. Immunol. 126:2123, 1981.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • D. Taramelli
    • 1
  • M. B. Bagley
    • 1
  • H. T. Holden
    • 1
  • L. Varesio
    • 1
  1. 1.Laboratory of ImmunodiagnosisNational Cancer InstituteBethesdaUSA

Personalised recommendations