Activation of Tumoricidal and/or Suppressor Macrophages: Different Stimulatory Signals Trigger Either Function both in Vivo and In Vitro

  • D. Taramelli
  • M. B. Bagley
  • H. T. Holden
  • L. Varesio
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


Macrophages upon in vivo and in vitro stimulation become activated and manifest functional and morphological characteristics either not present or differently expressed in non-stimulated macrophage populations (1–4). Antithetical functions can be exerted by a given macrophage population. For instance, cytotoxic macrophages could contribute to the elimination of infectious agents or to the control of neoplastic growth. On the other hand, by inhibiting certain immune responses, suppressor macrophages could impair host defense mechanisms.


Migration Inhibitory Factor None None Macrophage Population 51Cr Release Tumor Cytotoxicity 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • D. Taramelli
    • 1
  • M. B. Bagley
    • 1
  • H. T. Holden
    • 1
  • L. Varesio
    • 1
  1. 1.Laboratory of ImmunodiagnosisNational Cancer InstituteBethesdaUSA

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