Activation of Tumoricidal and/or Suppressor Macrophages: Different Stimulatory Signals Trigger Either Function both in Vivo and In Vitro
Macrophages upon in vivo and in vitro stimulation become activated and manifest functional and morphological characteristics either not present or differently expressed in non-stimulated macrophage populations (1–4). Antithetical functions can be exerted by a given macrophage population. For instance, cytotoxic macrophages could contribute to the elimination of infectious agents or to the control of neoplastic growth. On the other hand, by inhibiting certain immune responses, suppressor macrophages could impair host defense mechanisms.
KeywordsMigration Inhibitory Factor None None Macrophage Population 51Cr Release Tumor Cytotoxicity
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