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Macrophages and Cancer Metastasis

  • Isaiah J. Fidler
  • George Poste
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)

Abstract

Metastasis is the principal cause of failure in the treatment of cancer. There are several reasons for the failure to treat metastasis. First, at time of diagnosis and excision of primary tumors, metastasis may have already occurred, but the lesions are often too small to be detected. Moreover, widespread dissemination of metastases frequently takes place before symptoms of disease occur. Second, the anatomic location of many metastases may limit the effective dose of therapeutic agents that can be delivered to the lesions without being toxic to normal tissues or the host. The most formidable problem, however, is the heterogeneous nature of malignant neoplasms which leads to the rapid emergence of metastases that are resistant to conventional therapy (1,2).

Keywords

Cancer Metastasis Macrophage Infiltration Multilamellar Vesicle Muramyl Dipeptide Macrophage Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hart, I. R., and Fidler, I. J., Biochim. Biophys. Acta 651:37, 1981.PubMedCrossRefGoogle Scholar
  2. 2.
    Poste, G., and Fidler, I. J., Nature 283:139, 1980.PubMedCrossRefGoogle Scholar
  3. 3.
    Fidler, I. J., Cancer Res. 38:2651, 1978.PubMedGoogle Scholar
  4. 4.
    Fidler, I. J., and Poste, G., in “Tumor Cell Heterogeneity” (A. Owens, ed.), Fourth Bristol-Myers Symposium, in press.Google Scholar
  5. 5.
    Fidler, I. J., and Kripke, M. L., Science 197:893, 1977.PubMedCrossRefGoogle Scholar
  6. 6.
    Kripke, M. L., Gruys, E., and Fidler, I. J., Cancer Res. 38:2962, 1978.PubMedGoogle Scholar
  7. 7.
    Tsuruo, T., and Fidler, I. J., Cancer Res. 41:3058, 1981.PubMedGoogle Scholar
  8. 8.
    Cifone, M. A., and Fidler, I. J., Proc. Natl. Acad. Sci. USA 78:6949, 1981.PubMedCrossRefGoogle Scholar
  9. 9.
    Prehn, R. T., J. Natl. Cancer Inst. 45:1039, 1970.PubMedGoogle Scholar
  10. 10.
    Hepner, G. H., in “Commentaries on Research in Breast Disease” (R. D. Bulbrook, and D. J. Taylor, eds.), Alan R. Liss, Inc., New York, 1979.Google Scholar
  11. 11.
    Kerbel, R. S., Nature 280:358, 1979.PubMedCrossRefGoogle Scholar
  12. 12.
    Fidler, I. J., and Kripke, M. L., Cancer Immunol. Immunother. 7:201, 1980.CrossRefGoogle Scholar
  13. 13.
    Hibbs, J. B. Jr., Lambert L. H. Jr., and Remington, J. S., Science 177:998, 1972.PubMedCrossRefGoogle Scholar
  14. 14.
    Norbury, K., and Kripke, M. L., J. Reticuloendothel. Soc. 26:827, 1979.PubMedGoogle Scholar
  15. 15.
    Sadler, T. E., Jones, P. D. E., and Castro, J. E., in “The Macrophage and Cancer” (K. James, B. McBride, and A. Stuart, eds.), pp. 155–163, Econoprint, Edinburgh, 1977.Google Scholar
  16. 16.
    Jones, P. D. E., and Castro, J. E., Br. J. Cancer 35:519, 1977.PubMedCrossRefGoogle Scholar
  17. 17.
    Montovani, A., Giavazzi, R., Polentarutti, N., Spreafico, F., and Gavattini, S., Int. J. Cancer 25:617, 1980.CrossRefGoogle Scholar
  18. 18.
    Fidler, I. J., Cancer Res. 34:1074, 1974.PubMedGoogle Scholar
  19. 19.
    Liotta, L. A., Gatozzi, C., Kleinerman, J., and Saidel, G., Br. J. Cancer 36:639, 1977.PubMedCrossRefGoogle Scholar
  20. 20.
    Fidler, I. J., Fogler, W. E., Connor, J., in: “Immunobiology and Immunotherapy of Cancer” (W. D. Terry, and Y. Yamamura, eds.), pp. 361–375, Elsevier, New York, 1979.Google Scholar
  21. 21.
    Den Otter, W., Dullens Hub, F. J., Van Lovern, H., and Pels, E., in: “The Macrophage and Cancer”, (K. James, B. McBride, and A. Stuart, eds.), pp. 119–141, Econoprint, Edinburgh, 1977.Google Scholar
  22. 22.
    Mantovani, A., Int. J. Cancer 22:741, 1978.PubMedCrossRefGoogle Scholar
  23. 23.
    Russell, S. W., and McIntosh, A. T., Nature 268:69, 1977.PubMedCrossRefGoogle Scholar
  24. 24.
    Eccles, S. A., in: “Immunological Aspects of Cancer” (J. E. Castro, ed.), pp. 123–154, MTP Press, Lancaster, England, 1978.CrossRefGoogle Scholar
  25. 25.
    Eccles, S. A., and Alexander, P., Nature 250:667, 1974.PubMedCrossRefGoogle Scholar
  26. 26.
    Talmadge, J. E., Key, M., and Fidler, I. J., J. Immunol., in press.Google Scholar
  27. 27.
    Evans, R., and Lawler, E. M., Int. J. Cancer 26:831, 1980.PubMedCrossRefGoogle Scholar
  28. 28.
    Evans, R., and Eidlen, D. M., J. Reticuloendothel. Soc. 30:425, 1981.PubMedGoogle Scholar
  29. 29.
    Kerbel, R. S., and Twiddy, R. R., in.: “Contemporary Topics in Immunology” (I. P. Witz, and M. G. Hanna, Jr. eds.), pp. 239–254, Plenum Press, New York, 1980.Google Scholar
  30. 30.
    Hewitt, H. B., Blake, E. R., and Walder, A. S., Br. J. Cancer 33:241, 1976.PubMedCrossRefGoogle Scholar
  31. 31.
    Dvorak, H. R., Dickersin, G. R., Dvorak, A. M., Manseau, E. J., and Pyne, K., J. Natl. Cancer Inst. 67:335, 1981.PubMedGoogle Scholar
  32. 32.
    Key, M., Talmade, J. E., and Fidler, I. J., J. Immunol., submitted.Google Scholar
  33. 33.
    Nash, J. R. G., Price, J. E., and Tarin, D., Br. J. Cancer 39:478, 1981.CrossRefGoogle Scholar
  34. 34.
    Mantovani, A., Int. J. Cancer 27:221, 1981.PubMedCrossRefGoogle Scholar
  35. 35.
    Lederer, E., J. Med. Chem. 23:819, 1980.PubMedCrossRefGoogle Scholar
  36. 36.
    Chedid, L., Carelli, L., and Audibert, F., J. Reticuloendothel. Soc. 26:631, 1979.PubMedGoogle Scholar
  37. 37.
    Fidler, I. J., and Raz, A., in: “Lymphokines” Vol. 3 (E. Pick, ed.), pp. 345–363, Academic Press, New York, 1981.Google Scholar
  38. 38.
    Fidler, I. J., Isr. J. Med. 14:177, 1978.Google Scholar
  39. 39.
    Hibbs, J. B. Jr., J. Natl. Cancer Inst. 53:1287, 1974.Google Scholar
  40. 40.
    Fidler, I. J., and Cifone, M. A., Am. J. Pathol. 97:633, 1979.PubMedGoogle Scholar
  41. 41.
    Hanna, N., and Fidler, I. J., J.Natl. Cancer Inst. 66:1183, 1981.Google Scholar
  42. 42.
    Fidler, I. J., Gersten, D. M., and Budmen, M., Cancer Res. 36:3608, 1976.PubMedGoogle Scholar
  43. 43.
    Fidler, I. J., Roblin, R. O., and Poste, G., Cell. Immunol. 38:131, 1978.PubMedCrossRefGoogle Scholar
  44. 44.
    Sone, S., and Fidler, I. J., Cancer Res. 41:2401, 1981.PubMedGoogle Scholar
  45. 45.
    Papermaster, B. W., Holtermann, O. A., Rosner, D., Klein, E., Dae, T., and Djerassi, I., Res. Commun. Chem. Pathol. Pharmacol. 8:413, 1974.PubMedGoogle Scholar
  46. 46.
    Salvin, S. B., Youngner, J. S., Nishio, J., and Neta, R., J. Natl. Cancer Inst. 55:1233, 1975.PubMedGoogle Scholar
  47. 47.
    Poste, G., and Kirsh, R., Cancer Res. 39:2582, 1979.PubMedGoogle Scholar
  48. 48.
    Parant, M., Parant, F., Chedid, L., Yapo, A., Petit, J. R., and Lederer, E. Int. J. Immunopharmacol. 1:35, 1979.PubMedCrossRefGoogle Scholar
  49. 49.
    Sone, S., and Fidler, I. J., Cell.Immunol. 57:42, 1981.PubMedCrossRefGoogle Scholar
  50. 50.
    Allison, A. C., J. Reticuloendothel. Soc. 16:619, 1979.Google Scholar
  51. 51.
    Poste, G., Kirsh, R., Fogler, W., and Fidler, I. J., Cancer Res. 39:881, 1979.PubMedGoogle Scholar
  52. 52.
    Sone, S., and Fidler, I. J., J. Immunol. 125:2454, 1980.PubMedGoogle Scholar
  53. 53.
    Fogler, W. E., Raz, A., and Fidler, I. J., Cell. Immunol. 53:214, 1980.PubMedCrossRefGoogle Scholar
  54. 54.
    Fidler, I. J., Science 208:1469, 1980.PubMedCrossRefGoogle Scholar
  55. 55.
    Fidler, I. J., Raz, A., Fogler, W. E., Kirsh, R., Bugelski, P., and Poste, G., Cancer Res. 40:4460, 1980.PubMedGoogle Scholar
  56. 56.
    Poste, G., Kirsh, R., and Fidler, I. J., Cell. Immunol. 44:71, 1979.PubMedCrossRefGoogle Scholar
  57. 57.
    Poste, G., Am. J. Pathol. 96:595, 1979.PubMedGoogle Scholar
  58. 58.
    Poste, G., Kirsh, R., Fogler, W. E., and Fidler, I. J. Cancer Res. 39:881, 1979.PubMedGoogle Scholar
  59. 59.
    Fidler, I. J., Sone, S., Fogler, W. E., and Barnes, Z. L., Proc. Natl. Acad. Sci. USA 78:1680, 1981.PubMedCrossRefGoogle Scholar
  60. 60.
    Fidler, I. J., Barnes, Z., Fogler, W. E., Kirsh, R., Bugelski, P., and Poste, G., Cancer Res. in press.Google Scholar
  61. 61.
    Hart, I. R. Fogler, W. E., Poste, G., and Fidler, I. J., Cancer Immunol. Immunother. 10:157, 1981.CrossRefGoogle Scholar
  62. 62.
    Griswold, D. P. Jr., Cancer Chemother. Rep. 3:315, 1972.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Isaiah J. Fidler
    • 1
  • George Poste
    • 2
  1. 1.Cancer Metastasis and Treatment LaboratoryNCI-Frederick Cancer Research FacilityFrederickUSA
  2. 2.Smith Kline and French LaboratoriesPhiladelphiaUSA

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