Extrinsic Regulation of Macrophage Function by Lymphokines — Effect of Lymphokines on the Stimulated Oxidative Metabolism of Macrophages

  • Edgar Pick
  • Yael Bromberg
  • Maya Freund
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


Macrophage function is subject to multifactorial regulation, the details of which are only partially understood. The main determinants are: the stage of cell differentiation (maturation), the tissue localization, and the acute or chronic exposure to soluble or cellular elements interacting with the macrophage membrane. This last category is composed of a large number of unrelated agents and includes immunoglobulins, complement components, clotting factors, hormones and neurotransmitters, serum-derived lipoproteins and anti-proteases, bacterial products and, of special relevance to this presentation, lymphokines. Macrophages are also subject to autoregulatory influences by such products as oxygen radicals, prostaglandins (and other arachidonate metabolites), complement components and interferon.


Glutathione Peroxidase NADPH Oxidase Migration Inhibitory Factor Phorbol Myristate Acetate Oxidative Burst 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    North, R. J., J. Immunol. 121:806, 1978.PubMedGoogle Scholar
  2. 2.
    Cohn, Z. A., J. Immunol. 121:813, 1978.PubMedGoogle Scholar
  3. 3.
    Ögmunsdottir, H. M., and Weir, D. M., Clin. Exp. Immunol. 40:223, 1980.Google Scholar
  4. 4.
    North, R. J., Lymphokines 3:1, 1981.Google Scholar
  5. 5.
    Mackaness, G. B., J. Exp. Med. 120:105, 1964.PubMedCrossRefGoogle Scholar
  6. 6.
    Nathan, C. F., and Root, R. K., J. Exp. Med. 146:1648, 1977.PubMedCrossRefGoogle Scholar
  7. 7.
    Johnston, R. B., Godzik, C. A., and Cohn, Z. A., J. Exp Med. 148:115, 1978.PubMedCrossRefGoogle Scholar
  8. 8.
    Nathan, C. F., Nogueira, N., Juangbhanich, C., Ellis, J., and Cohn, Z. A., J. Exp. Med. 149:1056, 1979.PubMedCrossRefGoogle Scholar
  9. 9.
    Murray, H. W., and Cohn, Z. A., J. Exp. Med. 152:1596, 1980.PubMedCrossRefGoogle Scholar
  10. 10.
    Johnston, R. B., Lymphokines 3:33, 1981.Google Scholar
  11. 11.
    Vogel, S. N., and Rosenstreich, D. L., Lymphokines 3:149, 1981.Google Scholar
  12. 12.
    Olds, R. G., Ellner, J. J., El Kholy, A., and Mahmoud, A. A. F., J. Immunol. 127:1538, 1981.PubMedGoogle Scholar
  13. 13.
    David, J. R., and Remold, H. G., in “The Immunobiology of the Macrophage” (D. S. Nelson, ed.), pp. 401–426, Academic Press, New York, 1976.Google Scholar
  14. 14.
    Pick, E., and Keisari, Y., Cell. Immunol. 59:301, 1981.PubMedCrossRefGoogle Scholar
  15. 15.
    Bromberg, Y., and Pick, E., submitted for publication.Google Scholar
  16. 16.
    Pick, E., Charon, J., Mizel, D., J. Reticuloendothel. Soc. 30:581, 1981.PubMedGoogle Scholar
  17. 17.
    Keisari, Y., and Pick, E., Cell. Immunol. 62:172, 1981.PubMedCrossRefGoogle Scholar
  18. 18.
    Bellavite, P., Berton, G., Dri, P., and Soranzo, M. R., J. Reticuloendothel. Soc. 29:47, 1981.PubMedGoogle Scholar
  19. 19.
    Hirata, F., and Axelrod, J., Science 209:1082, 1980.PubMedCrossRefGoogle Scholar
  20. 20.
    Pick, E., and Mizel, D., submitted for publication.Google Scholar
  21. 21.
    Soberman, R. J., and Karnovsky, M. L., J. Exp. Med. 152:241, 1980.PubMedCrossRefGoogle Scholar
  22. 22.
    Pike, M. C., and Snyderman, R., J. Immunol. 127:1444, 1981.PubMedGoogle Scholar
  23. 23.
    Kröner, E. E., Peskar, B. A., Fischer, H., and Ferber, E., J. Biol. Chem. 256:3690, 1981.PubMedGoogle Scholar
  24. 24.
    Pick, E., Keisari, Y., and Bromberg, Y., in “Advances in Allergology and Applied Immunology” (A. Oehling, ed.), pp. 399–407, Pergamon Press, London, 1980.Google Scholar
  25. 25.
    Pick, E., Keisari, Y., Jakubowski, A., Bromberg, Y., and Freund, M., in “Lymphokines and Thymic Hormones” (A. L. Goldstein and M. A. Chirigos, eds.), pp. 177–185, Raven Press, New York, 1981.Google Scholar
  26. 26.
    Pabst, M. J., and Johnston, R. B., J. Exp. Med. 151:101, 1980.PubMedCrossRefGoogle Scholar
  27. 27.
    Cummings, N. P., Pabst, M. J., and Johnston, R. B., J. Exp. Med. 152:1659, 1980.PubMedCrossRefGoogle Scholar
  28. 28.
    Johnston, R. B., Chadwick, D. A., and Cohn, Z. A., J. Exp. Med. 153:1678, 1981.PubMedCrossRefGoogle Scholar
  29. 29.
    Allred, C. D., and Hill, H. R., Infect. Immun. 19:833, 1978.PubMedGoogle Scholar
  30. 30.
    Van Epps, D. E., and Garcia, M. L., J. Clin. Invest. 66:167, 1980.PubMedCrossRefGoogle Scholar
  31. 31.
    English, D., Roloff, J. S., and Lukens, J. N., Blood 58:129, 1981.PubMedGoogle Scholar
  32. 32.
    Issekutz, A. C., Lee, K. Y., and Biggar, W. D., Infect. Immun. 24:295, 1979.PubMedGoogle Scholar
  33. 33.
    Murray, H. W., Nathan, C. F., and Cohn, Z. A., J. Exp. Med. 152:1610, 1980.PubMedCrossRefGoogle Scholar
  34. 34.
    Pick, E., Keisari, Y., Bromberg, Y., Freund, M., and Jakubowski, A., in “Heterogeneity of Mononuclear Phagocytes” (O. Förster and M. Landy, eds.), pp. 331–336, Academic Press, New York, 1981.Google Scholar
  35. 35.
    Rister, M., and Baehner, R. L., J. Clin. Invest. 58:1174, 1976.PubMedCrossRefGoogle Scholar
  36. 36.
    Murray, H. W., J. Exp. Med. 153:1690, 1981.PubMedCrossRefGoogle Scholar
  37. 37.
    Ando, M., Suga, M., Shima, K., Takenaka, S., and Tokuomi, H., Kumamoto Med. J. 29:88, 1976.PubMedGoogle Scholar
  38. 38.
    Krueger, G. G., Ogden, B. E., and Weston, W. L., Clin. Exp. Immunol. 23:517, 1976.PubMedGoogle Scholar
  39. 39.
    Alföldy, P., and Lemmel, E. M., Clin. Immunol. Immunopathol. 12:263, 1979.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Edgar Pick
    • 1
  • Yael Bromberg
    • 1
  • Maya Freund
    • 1
  1. 1.Section of Immunology Department of Human Microbiology Sackler School of MedicineTel-Aviv UniversityTel-AvivIsrael

Personalised recommendations