Human Mononuclear Phagocytes Differentiation Antigens

  • Alexandra Dimitriu-Bona
  • Robert J. Winchester
  • Gerd R. Burmester
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


Through a series of irreversible events, the progenitor cell committed to the mononuclear phagocyte lineage differentiates into blood monocytes and fluid or tissue macrophages. These successive maturational events, as well as reversible modulations induced by certain local stimuli, reflect the expression of specific gene products and the repression of others. Taken together they explain the morphological, functional and biochemical heterogeneity that characterizes the diverse members of this cell lineage. The analysis of these gene products found on the mononuclear phagocyte membrane has recently been approached through the use of monoclonal antibody technology (1–3). This report is a summary of studies on the mononuclear phagocyte cell surface phenotype utilizing a series of monoclonal antibodies developed in this laboratory (4,5).


U937 Cell Blood Monocyte Mononuclear Phagocyte Tissue Macrophage Complement Mediate Lysis 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Alexandra Dimitriu-Bona
    • 1
  • Robert J. Winchester
    • 1
  • Gerd R. Burmester
    • 1
  1. 1.Hospital for Joint DiseasesMount Sinai School of MedicineNew YorkUSA

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