Antigenic Markers on Human Monocytes and Macrophages

  • Robert F. ToddIII
  • Stuart F. Schlossman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


In an effort to examine heterogeneity within the human reticulo-endothelial system, we have developed a panel of monoclonal antibodies that define the expression of five distinct, nonpolymorphic antigens displayed on the surface of monocytes, macrophages and platelets (1,2). Antigen Mol is shared by peripheral blood monocytes, granulocytes, and a subset of Null cells. The expression of Mo2 and Mo3 is restricted to the monocyte-macrophage lineage. The density of Mo3, as distinguished from Mo2, is low on freshly isolated monocytes, but increases as a function of time in culture. Mo4 is borne by both monocytes and platelets, while Plt-1 is a platelet-specific antigen whose detection on monocytes reflects adsorption of platelets to monocyte surfaces. Mo1–4 are expressed by cultured macrophages derived from peripheral blood monocytes while only Mo1, 2, and 4 are borne by human peritoneal macrophages. Evidence for these conclusions will be presented and the significance of the Mo antigen series as differentiation markers within the monocyte-macrophage lineage will be discussed.


Acute Lymphocytic Leukemia Peritoneal Macrophage Peripheral Blood Monocyte Myeloid Leukemia Cell Null Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Todd, R. F., Nadler, L. M., and Schlossman, S. F., J. Immunol. 126:1435, 1981.PubMedGoogle Scholar
  2. 2.
    Todd, R. F., and Schlossman, S. F., Blood 59:775, 1982.PubMedGoogle Scholar
  3. 3.
    Pertoft, H., Johnsson, A., Warmegard, B., and Seljeld, R., J. Immunol. Meth. 33:221, 1980.Google Scholar
  4. 4.
    Levy, P. C., Shaw, G. M., and Lobuglio, A. G., J. Immunol. 123:594, 1979.PubMedGoogle Scholar
  5. 5.
    Chess, L., MacDermott, R. P., and Schlossman, S. F., J. Immunol. 113:1113, 1974.PubMedGoogle Scholar
  6. 6.
    Todd, R. F., Griffin, J. D., Ritz, J., Nadler, L. M., Abrams, T., and Schlossman, S. F., Leukemia Res. 5:491, 1981.CrossRefGoogle Scholar
  7. 7.
    Perussia, B., Jankiewicz, J., and Trinchieri, G., Blood, in press.Google Scholar
  8. 8.
    Elias, L., Wogenrich, F. J., Wallace, J. M., and Longmire, J., Leukemia Res. 4:301, 1980.CrossRefGoogle Scholar
  9. 9.
    Rovera, G., Santoli, D., and Damsky, C., Proc. Natl. Acad. Sci. USA 76:2779, 1979.PubMedCrossRefGoogle Scholar
  10. 10.
    Unanue, E. R., Immunol. Rev. 40:227, 1978.PubMedCrossRefGoogle Scholar
  11. 11.
    Nathan, D. F., Murray, H. W., and Cohn, Z. A., New Engl. J. Med. 303:622, 1980.PubMedCrossRefGoogle Scholar
  12. 12.
    Poplack, D. G., Bonnard, G. D., Holiman, B. J., and Blaese, R. M., Blood 48:309, 1976.Google Scholar
  13. 13.
    Mantovani, A., Jerrells, T. R., Dean, J. H., and Herberman, R. B., Int. J. Cancer 23:18, 1979.PubMedCrossRefGoogle Scholar
  14. 14.
    Morimoto, C., Todd, R. F., Distaso, J. A., and Schlossman, S. F., J. Immunol. 127:1137, 1981.PubMedGoogle Scholar
  15. 15.
    Zuckerman, S. H., Ackerman, S. K., and Douglas, S. D., Immunol. 38:401, 1979.Google Scholar
  16. 16.
    Breard, J., Reinherz, E. L., Kung, P. C., Goldstein, G., and Schlossman, S. F., J. Immunol. 124:1943, 1980.PubMedGoogle Scholar
  17. 17.
    Raff, H. V., Picker, L. J., and Stobo, S. D., J. Exp. Med. 152:581, 1980.PubMedCrossRefGoogle Scholar
  18. 18.
    Hogg, N., Slusarenko, M., Cohen, J., and Reiser, J., Cell 24:875, 1981.PubMedCrossRefGoogle Scholar
  19. 19.
    Ugolini, V., Nunez, G., Smith, R. G., Stastny, P., and Capra, J. D., Proc. Natl. Acad. Sci. USA 77:6764, 1980.PubMedCrossRefGoogle Scholar
  20. 20.
    Dimitriu-Bona, A., Burmester, G. R., Waters, S. J., and Winchester, R. J., Fed. Proc. 40:988, 1981.Google Scholar
  21. 21.
    Linker-Israeli, M., Billing, R. J., Foon, K. A., Fitchen, J. H., and Terasaki, P. I., J. Immunol. 127:2473, 1981.PubMedGoogle Scholar
  22. 22.
    Springer, T., Galfre, G., Secher, D. S., and Milstein, C., Eur. J. Immunol. 9:301, 1979.PubMedCrossRefGoogle Scholar
  23. 23.
    Griffin, J. D., Ritz, J., Nadler, L. M., and Schlossman, S. F., J. Clin. Invest. 68:932, 1981.PubMedCrossRefGoogle Scholar
  24. 24.
    Perussia, B., Trinchieri, G., Lebman, D., Jankiewicz, J., Lange, B., and Rovera, G., Blood, in press.Google Scholar
  25. 25.
    Austyn, J. M., and Gordon, S., Eur. J. Immunol. 11:805, 1981.PubMedCrossRefGoogle Scholar
  26. 26.
    Todd, R. F., and Schlossman, S. F., in “Immunology of the Reticuloendothelial System. A Comprehensive Treatise. Vol. VI” (J. A. Bellante and H. B. Herscowitz, eds.), Plenum Press, New York, 1981.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Robert F. ToddIII
    • 1
  • Stuart F. Schlossman
    • 1
  1. 1.Division of Tumor Immunology Sidney Farber Cancer Institute and Department of MedicineHarvard Medical SchoolBostonUSA

Personalised recommendations