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Differentiation Antigens and Macrophage Heterogeneity

  • Siamon Gordon
  • Stan Hirsch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)

Abstract

The macrophage provides a favorable system to study differentiation in eukaryotic cells. Multipotential hemopoietic precursors proliferate and differentiate in response to ill-defined signals and are then widely distributed via the blood stream as mature members of the “Mononuclear Phagocyte System”. Macrophages in the periphery display heterogeneous properties depending on their site and adaptation to local inflammatory and microbial agents. Although different lineages derive from the same stem cell, mature macrophages can be readily distinguished from polymorphonuclear leukocytes (PMN), other granulocytes, lymphocytes and dendritic cells. The myelomonocytic cells derive from a common bipotential precursor (CFU-C) which gives rise to colonies of macrophages and/or PMN in culture in the presence of specific colony stimulating factors (CSF). However, commitment to the macrophage or PMN lineage is poorly understood.

Keywords

Peritoneal Macrophage Cell Conditioned Medium Macrophage Differentiation Mononuclear Phagocyte System Nucleotidase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Siamon Gordon
    • 1
  • Stan Hirsch
    • 1
  1. 1.Sir William Dunn School of PathologyUniversity of OxfordOxfordUK

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