Inhibitors of Monocyte Responses to Chemotaxins are Associated with Human Neoplasms

  • Ralph Snyderman
  • George Cianciolo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


Macrophages can destroy cancer cells in vivo and in vitro (1–3) but low numbers of macrophages are generally found within progressively growing tumors. Moreover, a tumor’s metastatic potential is often inversely related to the number of macrophages which it contains (4,5). As a group, cancer patients have abnormally functioning monocytes which regain normal function after successful cancer therapy or surgical tumor removal (6–10). Therefore, we have hypothesized that cancer cells may produce factors that alter monocyte-macrophage functions, thereby subverting immune surveillance (11). Indeed, in rodents neoplasms produce agents which inhibit macrophage accumulation in vivo and macrophage chemotaxis in vitro (12–15).


Pleural Fluid Chemotaxis Assay Monocyte Function Destroy Cancer Cell Macrophage Chemotaxis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Cerottini, J. C., and Brunner, K. T., Adv. Immunol. 18:67, 1974.PubMedCrossRefGoogle Scholar
  2. 2.
    Levy, M. H., and Wheelock, E. F., Adv. Cancer Res. 20:131, 1974.PubMedCrossRefGoogle Scholar
  3. 3.
    Shin, H. S., Hayden, M., Langley, S., Kaliss, N., and Smith, M. R., J. Immunol. 114:1255, 1975.PubMedGoogle Scholar
  4. 4.
    Eccles, S. A., and Alexander, P., Nature 250:667, 1974.PubMedCrossRefGoogle Scholar
  5. 5.
    Russell, S. W., and McIntosh, A. T., Nature 268:69, 1977.PubMedCrossRefGoogle Scholar
  6. 6.
    Boetcher, D. A., and Leonard, E. J., J. Natl. Cancer Inst. 52:1091, 1974.PubMedGoogle Scholar
  7. 7.
    Hausman, M. S., Brosman, S., Snyderman, R., Mickey, M. R., and Fahey, J., J. Natl. Cancer Inst. 55:1047, 1975.PubMedGoogle Scholar
  8. 8.
    Rubin, R. H., Cosimi, A. B., and Goetzl, E. J., Clin. Immunol. Immunopathol. 6:376, 1976.PubMedCrossRefGoogle Scholar
  9. 9.
    Snyderman, R., Seigler, H. F., and Meadows, L., J. Natl. Cancer Inst. 58:37, 1977.PubMedGoogle Scholar
  10. 10.
    Snyderman, R., Meadows, L., Holder, W., and Wells, S., J. Natl. Cancer Inst. 60:737, 1978.PubMedGoogle Scholar
  11. 11.
    Adams, D. O., and Snyderman, R., J. Natl. Cancer Inst. 62:1341, 1979.PubMedGoogle Scholar
  12. 12.
    Snyderman, R., and Pike, M. C., Science 192:370, 1976.PubMedCrossRefGoogle Scholar
  13. 13.
    Normann, S. J., and Sorkin, E., J. Natl. Cancer Inst. 57:135, 1976.Google Scholar
  14. 14.
    Stevenson, M. M., and Meltzer, M. S., J. Natl. Cancer Inst. 57:847, 1976.PubMedGoogle Scholar
  15. 15.
    Nelson, M., and Nelson, D. S., Immunology 34:277, 1978.PubMedGoogle Scholar
  16. 16.
    Snyderman, R., Pike, M. C., Blaylock, B. L., and Weinstein, P., J. Immunol. 116:585, 1976.PubMedGoogle Scholar
  17. 17.
    Snyderman, R., and Cianciolo, G. J., J. Reticuloendothelial Soc. 26:453, 1979.Google Scholar
  18. 18.
    Cianciolo, G. J., Herberman, R. B., and Snyderman, R., J. Natl. Cancer Inst. 65:829, 1980.PubMedGoogle Scholar
  19. 19.
    Fauve, R. M., Hevin, B., Jacob, H., Gaillard, J. A., and Jacob, F., Proc. Natl. Acad. Sci USA 71:4052, 1974.PubMedCrossRefGoogle Scholar
  20. 20.
    North, R. J., Kirstein, D. P., and Tuttle, R. L., J. Exp. Med. 143:559, 1976.PubMedCrossRefGoogle Scholar
  21. 21.
    Snyderman, R., Siegler, H., and Meadows, L., J. Natl. Cancer Inst. 58:37, 1977.PubMedGoogle Scholar
  22. 22.
    Brozna, J. P., and Ward, P. A., J. Clin. Invest. 64:302, 1979.PubMedCrossRefGoogle Scholar
  23. 23.
    Normann, S. J., Schardt, M., and Sorkin, E., J. Natl. Cancer Inst. 63:825, 1979.PubMedGoogle Scholar
  24. 24.
    Cianciolo, G. J., Matthews, T. J., Bolognesi, D. P., and Snyderman, R., J. Immunol. 124:2900, 1980.PubMedGoogle Scholar
  25. 25.
    Cianciolo, G. J., and Snyderman, R., J. Clin. Invest. 67:60, 1981.PubMedCrossRefGoogle Scholar
  26. 26.
    Cianciolo, G. J., Hunter, J., Silva, J., Haskill, J. S., and Snyderman, R., J. Clin. Invest. 68:831, 1981.PubMedCrossRefGoogle Scholar
  27. 27.
    Wilson, J., and Snyderman, R., Clin. Res. 26:378A, 1978.Google Scholar
  28. 28.
    Cianciolo, G. J., and Snyderman, R., Fed. Proc., in press, 1982.Google Scholar
  29. 29.
    Cianciolo, G. J., Bolognesi, D. P., and Snyderman, R., Fed. Proc. 39 (3):478A, 1980.Google Scholar
  30. 30.
    Thiel, H. J., Broughton, E. M., Matthews, T. J., Schafer, W., and Bolognesi, D. P., Virology 111:270, 1981.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Ralph Snyderman
    • 1
  • George Cianciolo
    • 1
  1. 1.Laboratory of Immune Effector Function Howard Hughes Medical Institute Division of Rheumatic and Genetic Diseases Department of Medicine and Department of Microbiology and ImmunologyDuke University Medical CenterDurhamUSA

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