Weak-Base Induced Lysosomal Secretion by Macrophages: An Alternative Trigger Mechanism that is Independent of Complement Activation
The abundance of mononuclear phagocytes at inflammatory sites has stimulated much interest in their pathological roles. In vitro investigations have indicated that these cells are amply equipped to promote an inflammatory response, following suitable stimulation, by the synthesis and secretion of a variety of biologically active products such as complement proteins (1), prostaglandins (2), neutral proteinases (3,4), and lysosomal acid hydrolases (5,6,7). Whereas the nature of these secretory products has been well characterized, the biochemical pathways underlying the triggering of their release remain only poorly understood.
KeywordsPhenylmethylsulphonyl Fluoride Zymosan Particle Serine Esterase Hexose Monophosphate Shunt Lysosomal Secretion
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