Synthesis and Release of Lytic Enzymes by Macrophages in Chronic Inflammation
Knowledge about the secretory repertoire of macrophages is expanding very rapidly. Many molecules have been identified as products of these cells, and it may sound old-fashioned to keep talking about lytic enzymes. Due to their ability to degrade a great variety of biological molecules, however, the secretory enzymes of macrophages are a major factor in many pathological processes. Two types of effects are particularly important: tissue damage resulting from the breakdown of extracellular connective tissue structures and the conditioning of the pericellular environment. Lytic enzymes are also useful experimental parameters. They are among the best-defined truly secretory molecules of the macrophage and are easy to assay. For this reason, the rate of secretion of certain hydrolases is often adopted as a marker of macrophage function.
KeywordsPlasminogen Activator Respiratory Burst Mononuclear Phagocyte Enzyme Secretion Lytic Enzyme
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