Selection of an Immunogenic 3LL Tumor Subline Following Serial Growth In Vivo in the Local Presence of Peritoneal Macrophages
Macrophages may play a role in host defense against neoplasia since they inhibit the growth of tumors at primary (1) and metastatic sites (2). In contrast, some reports indicate that macrophages may promote tumor development in several ways such as induction of clonal proliferation of malignant cells (3) or activation of tumor mediated suppressor mechanisms (4). The diverse and of ten contradictory effects of macrophages can be explained by the functional heterogeneity of macrophage populations (5).
KeywordsPeritoneal Macrophage Experimental Metastasis Thymidine Uptake Local Presence Spontaneous Metastasis
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- 1.Den Otter, W., Dullens Hub, F. S., Van Lovern, H., and Pels, E., in “The Macrophage and Cancer” (K. James, B. McBride, and A. Stuart, eds.), P. 119, Econoprint, Edinburgh, 1977.Google Scholar