MG-1, Identification of an Early Differentiation Marker for Bone Marrow Cells in a Monocytic/Granulocytic Lineage

  • B. J. Mathieson
  • F.-W. Shen
  • A. Brooks
  • W. M. Leiserson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)

Abstract

Several reagents have been developed for use in different species that reportedly detect macrophages and subsets of bone marrow cells such as monocytes and granulocytes (1–5). At least two of these reagents are known to detect both mature macrophages and a. subset of bone marrow cells or myelocytic cells of mice (2,5). One of these reagents, 2.4G2, detects Fc receptors (FcR) on several different types of cells in mice (5). The other reagent defines another specificity known as Mac-1 that is different from FcR by molecular weight and tissue distribution. With the exception of the alloantiserum to Mph-1 (1), the other reagents (monoclonal antibodies) have been produced across xenotropic barriers and do not recognize genetic strain differences (2–5).

Keywords

Sucrose Albumin Agar Sedimentation Nylon 

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References

  1. 1.
    Archer, J. R., and Davies, D. A. L., J. Immunogenet. 1:113, 1974.CrossRefGoogle Scholar
  2. 2.
    Springer, T., Galfré, G., Secher, D. S., and Milstein, C., Eur. J. Immunol. 9:301, 1979.PubMedCrossRefGoogle Scholar
  3. 3.
    Breard, J., Reinherz, E. L., Kung, P. C., Goldstein, G., and Schlossman, S. F., J. Immunol. 124:1943, 1980.PubMedGoogle Scholar
  4. 4.
    Rumpold, H., Swetby, P., Boltz, G., and Förster, O., in “Heterogeneity of Mononuclear Phagocytes” (O. Förster and M. Landy, eds.), pp. 47–52, Academic Press, London, 1981.Google Scholar
  5. 5.
    Unkeless, J. C., Mellman, I. S., McGettigan, M., and Plutner, H., in “Heterogeneity of Mononuclear Phagocytes” (O. Förster and M. Landy, eds.), pp. 91–96, Academic Press, London, 1981.Google Scholar
  6. 6.
    Peterson, E. A., and Evans, W. H., Nature 214:824, 1967.PubMedCrossRefGoogle Scholar
  7. 7.
    Mathieson, B. J., Sharrow, S. O., Campbell, P. S., and Asofsky, R., Nature 277:478, 1979.PubMedCrossRefGoogle Scholar
  8. 8.
    Fowlkes, B. J., Waxdal, M. J., Sharrow, S. O., Thomas, C. A. III, Asofsky, R., and Mathieson, B. J., J. Immunol. 125:623, 1980.PubMedGoogle Scholar
  9. 9.
    Till, J. E., and McCulloch, E. A., Rad. Res. 14:213, 1961.CrossRefGoogle Scholar
  10. 10.
    Pluznik, D. H., and Sachs, L., Exp. Cell Res. 43:553, 1966.PubMedCrossRefGoogle Scholar
  11. 11.
    Bradley, T. R., and Metcalf, D., Aust. J. Biol. Med. Sci. 44:287, 1966.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • B. J. Mathieson
    • 1
  • F.-W. Shen
    • 2
  • A. Brooks
    • 3
  • W. M. Leiserson
    • 3
  1. 1.Basel Institute for ImmunologyBaselSwitzerland
  2. 2.Memorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.National Institute of Allergy and Infectious DiseasesBethesdaUSA

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