MG-1, Identification of an Early Differentiation Marker for Bone Marrow Cells in a Monocytic/Granulocytic Lineage
Several reagents have been developed for use in different species that reportedly detect macrophages and subsets of bone marrow cells such as monocytes and granulocytes (1–5). At least two of these reagents are known to detect both mature macrophages and a. subset of bone marrow cells or myelocytic cells of mice (2,5). One of these reagents, 2.4G2, detects Fc receptors (FcR) on several different types of cells in mice (5). The other reagent defines another specificity known as Mac-1 that is different from FcR by molecular weight and tissue distribution. With the exception of the alloantiserum to Mph-1 (1), the other reagents (monoclonal antibodies) have been produced across xenotropic barriers and do not recognize genetic strain differences (2–5).
KeywordsSucrose Albumin Agar Sedimentation Nylon
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