Pulmonary and Cardiovascular Pharmacology of Leukotrienes

  • Per Hedqvist
  • Sven-Erik Dahlén
  • Jakob Björk
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 54)


Leukotrienes rapidly gained widespread recognition as substan­ces of potentially great impact when slow reacting substance of ana­phylaxis (SRS-A) was shown to be included in this newly discovered family of arachidonic acid derivatives (Murphy et al., 1979; Bach et al.1980 a,b, Morris et al.,1980; Lewis et al., 1980 a). SRS-A was de­scribed as a smooth muscle stimulating principle more than 40 years ago (Kellaway and Trethewie, 1940), and is considered to be an im­portant mediator of the bronchospasm in asthma. SRS-A can now be identified as leukotriene C4 (LTC4) and its immediate metabolites leukotriene D4 (LTD4) and leukotriene E4 (LTE4) (cf. Lewis et al., 1980b,Samuelsson et al.,1980) (Fig. 1). three leukotrienes have recently proved to be outstanding bronchoconstrictors and vivid inducers of plasma exudation (Dahlén et al., 1980; Drazen et al., 1980; Hedqvist et al., 1980; Dahlén et al., 1981a),which has strength­ened the supposition that SRS-A has an important role in the mani­festations of hypersensitivity diseases.


Postcapillary Venule Plasma Leakage Insufflation Pressure Hamster Cheek Pouch Human Bronchus 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Per Hedqvist
    • 1
  • Sven-Erik Dahlén
    • 1
  • Jakob Björk
    • 2
  1. 1.Department of PhysiologyKarolinska InstitutetStockholmSweden
  2. 2.Department of Experimental MedicinePharmacia ABUppsalaSweden

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