Acute Arachidonate Toxicity

  • Adam Myers
  • Juan Penhos
  • Peter Ramwell
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 54)


Since the discovery by Silver et al. [1] that injection of arachidonic acid into the marginal ear vein of the rabbit induced sudden death, this method has gained wide acceptance as a technique for in vivo study of antithrombotic agents acting via arachidonic acid metabolites. Typically, the agent being studied is used to pretreat experimental animals, and the incidence of death of pretreated animals following intravenous sodium arachidonate infusion is compared to the mortality of nonpretreated animals. The cause of death has been shown to be occlusive pulmonary platelet aggregation [1]. Because this method is used to evaluate potential therapeutic agents, it is useful to consider the factors which regulate the mortality induced by arachidonate.


Arachidonic Acid Gonadal Steroid Gonadal Hormone Castrate Male Estradiol Benzoate 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Adam Myers
    • 1
  • Juan Penhos
    • 1
  • Peter Ramwell
    • 1
  1. 1.Department of Physiology and BiophysicsGeorgetown UniversityUSA

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