An in Vivo Aggregometer
The method of aggregometry introduced by Born  in 1962 has been used extensively to study platelet aggregation and disaggregation in vitro and ex vivo. Although it is generally accepted that in vitro data does not always reflect in vivo data , fewer studies have been undertaken on platelets in vivo. Such, in vivo studies are limited by the cumbersome and invasive nature of existing techniques  which has prompted development of a simple, minimally invasive technique for the continuous monitoring of radiolabeled platelets in vivo .
KeywordsPlatelet Aggregation Adenosine Diphosphate Prostaglandin Endoperoxide Coeliac Artery Study Platelet Aggregation
Unable to display preview. Download preview PDF.
- 1.G. V. R. Born, Quantitative investigations into the aggregation of blood platelets, J. Physiol., 162: 67 (1962).Google Scholar
- 2.P. Didisheim and V. Fuster, Actions and clinical status of platelet suppressive agents, sem hem., 15: 55–72 (1978).Google Scholar
- 3.G. M. Smith, A study of intravascular platelet aggregation by continuous platelet counting, TIPS, 2: 105–107 (1981).Google Scholar
- 4.O. J. Davies, J. Morley, C. Page, and W. Paul, In vivo aggregation of guinea-pig platelets, J. Physiol. (1981).Google Scholar
- 10.R. J. Gryglewski, R. Korbut, A. Ocetkiewicz, J. Splawinski, B. Wojtaszek, and J. Swies, Lungs as a generator of prostacylinHypothesis on physiological significance, Naunyn-Schmiedeberg’s Arch. Pharmacol., 304: 45–50 (1978).Google Scholar
- 11.J. Morley, C. P. Page, W. Paul, N. Monjelli, R. Cesarini, and C. Gandolfi, A comparative study of prostacyclin and two analogues (FCE 21258, FCE 21292) in various in vitro and in vivo systems, Prostaglandins and Med. (1981).Google Scholar
- 12.J. Morley, C. P. Page, and W. Paul, The effect of heparin on platelet aggregation in vivo, Brit. J. Pharm. (1981).Google Scholar