6-Keto-Prostaglandin E1: Biosynthesis and Circulatory Effects

  • Eric G. Spokas
  • John C. Mcgiff
  • Patrick Y.-K. Wong
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 54)


The changes in circulatory function induced by 6-keto-prostaglandin E1 (6-keto-PGE1) bear a close resemblance to the changes caused by prostacyclin (PGI2). Like PGI2, 6-keto-PGE1 is potent in stimulating renin secretion [l–3], inhibiting platelet aggregation [4], and reducing blood pressure and vascular resistance in diverse regional circulations [5, 6]. In this chaper, we present evidence that 6-keto-PGE1 may arise during the course of metabolic transformation of PGI2 through the activity of 9-hydroxyprostaglandin dehydrogenase (9-OH PGDH) identified in various tissues, including liver, blood platelets, and renal cortex. As PGI2 is unstable, having a half-life of approximately 3 min in aqueous solution [7], the identification of an active and stable metabolite of prostacyclin has important implications for understanding the time-dependency of prostacyclin-induced physiologic responses. In contrast to PGI2, when 6-keto-PGE1 is incubated in aqueous solution at pH 7.4, 37°C its platelet antiaggregatory activity remains undiminished for at least 20 min [3].


Platelet Aggregation Human Platelet Renal Cortex Inhibit Platelet Aggregation Renin Release 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Eric G. Spokas
    • 1
  • John C. Mcgiff
    • 1
  • Patrick Y.-K. Wong
    • 1
  1. 1.Department of PharmacologyNew York Medical CollegeValhallaUSA

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