Results of a Phase I/II Clinical Trial of Fractionated Hyperthermia in Combination with Low Dose Ionizing Radiation

  • Haim I. Bicher
  • Fred W. Hetzel
  • Taljit S. Sandhu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 157)


This paper addresses, in part, the current status of hyperthermia as a new clincal modality and reports the results of a large, prospective clinical trial employing microwave hyperthermia in combination with low doses of ionizing radiation. In the protocol employed, each treated area received 8 hyperthermia treatments of 1.5 hour combined with 1600 rad over a total period of 5 weeks. Patients were heated with microwaves of 915 or 300 MHz employing external applicators or internal intracavitary antennas. The results of this fractionation scheme are encouraging since in 121 fields that were treated completely according to protocol and were available for follow-up for at least 2 months, complete responses were observed in 65% of all cases, partial response in 30% and no response in only 5%. It is also important to note that toxicity was minimal throughout the study.


Total Response Anatanical Location Neck Node Metastasis Fractionation Regime Neck Recurrence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Arcangeli, G., Barni, E., Dividalli, A., et al. Effectiveness of microwave hyperthermia combined with ionizing radiation: clinical results on neck node metastases. Int. J. Radiat. Oncol. Biol. Phys. 1980; 6: 143–148.PubMedCrossRefGoogle Scholar
  2. 2.
    Bicher, H. I., Sandhu, T. S., Hetzel, F. W. Hyperthermia and radiation in combination: a clinical fractionation regime. Int. J. Radiat. Oncol. Biol. Phys. 1980; 6: 867–870.PubMedCrossRefGoogle Scholar
  3. 3.
    Hornback, N. B., Shupe, R. E., Homayon, S., et al. Preliminary clinical results of combined 433 MHz microwave therapy and radiation therapy on patients with advanced cancer. Cancer 1977; 40: 2354–2863.Google Scholar
  4. 4.
    Johnson, R. J. R., Sandhu, T. S., Hetzel, F. W., et al. A pilot study to investigate the therapeutic ratio of 41.5–42.0 C hyperthermia radiation. Int. J. Radiat. Oncol. Biol. Phys. 1979; 5: 947–953.PubMedCrossRefGoogle Scholar
  5. 5.
    Kim, J. H., Hahn, E. W., Benjamin, F. J. Treatment of superficial cancers by combination hyperthermia and radiation therapy. Clin. Bul. 1979; 9: 13–16.Google Scholar
  6. 6.
    Manning, M. R., Cetas, T., Boone, M. L. M., Miller, R. C. Clinical hyperthermia: results of the phase I clinical trial combining localized hyperthermia with or without radiation. (Abstr.) Int. J. Radiat. Oncol. Biol. Phys. 1979; 5: S2: 173.CrossRefGoogle Scholar
  7. 7.
    U. R., Noell, K. T., Woodward, K. T. et al. Microwave-induced local hyperthermia in combination with radiotherapy of human malignant tumors. Cancer 1980; 45: 638–646.PubMedCrossRefGoogle Scholar
  8. 8.
    Bicher, H. I., Hetzel, F. W., Sandhu, T. S., et al. Effects of hyperthermia on normal and tumor microenvironment. Radiology 1980; 137: 523–530.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Haim I. Bicher
    • 1
  • Fred W. Hetzel
    • 1
  • Taljit S. Sandhu
    • 1
  1. 1.Department of Therapeutic RadiologyHenry Ford HospitalDetroitUSA

Personalised recommendations