Abstract
It is a cammonplace that the cure rates of most types of cancer are far from total: surgical removal of tumors is often necessarily incomplete, all of the antitumor drugs have side effects, and irradiation includes several hazards and injuries as well.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Dethlefsen LA (ed.), The Third International Symposium: Cancer Therapy by Hyperthermia, Drugs and Radiation. Abstracts. Fort Collins, Co.: Colorado State Univ., June 22–26, 1980.
Warburg, O., The Metabolism of Tumors. London: Constable, 1930.
Voegtlin C., Fitch, R. H., Kahler, H., Johnson, J. M., Thompson, J. W., The influence of the parenteral administration of certain sugars on the pH of malignant tumors. Nat. Inst. Health Bull. 164: 1, 1935.
von Ardenne, M., Reitnauer, P. G., Schmidt, D., Theoretische Grundlagen und in-vivo-Messungen zur Optimierung der selektiven Ubersäuerung von Krebsgewebe. Acta Biol. Med. Germ. 22: 35, 1969.
von Ardenne, M., Reitnauer, P. G., Selektive Krebszellenschädigung durch Proteindenaturierung. Dtsch Gesundh-Wesen 23: 1681, 1968.
Freeman, M. L., Dewey, W. C., Hopwood, L. E., Effect of pH on hyperthermic cell survival. J. Natl. Cancer Inst. 58: 1837, 1977.
Gerweck, L. E., Modification of cell lethality at elevated temperatures. The pH effect. Radiation Res. 70: 224, 1977.
Gerweck, L. E., Jennings, M., Richards, B., Influence of pH on the response of cells to single and split doses of hyperthermia. Cancer Res. 40: 4019, 1980.
Gerweck, L. E., Richards, B., Influence of pH on the thermal sensitivity of cultured human glioblastoma cells. Cancer Res. 42: 845, 1981.
Overgaard, J., Influence of extracellular pH on the viability and morphology of tumor cell growth to hyperthermia. Cancer Res. 56: 1243, 1976.
Overgaard, J., Effect of hyperthermia on malignant cells in vivo. A review and a hypothesis. Cancer 39: 2637, 1977.
Overgaard, J. Nielsen, O. S., The role of tissue environmental factors on the kinetics and morphology of tumors exposed to hyperthermia. Ann NY Acad Sci. 335: 254, 1980.
von Ardenne, M., Krüger, W., Local tissue hyperacidification and lysosomes. In Dingle, J. T., Jacques, P. H., Shaw, I. H. (eds), Lysosomes in Applied Biology and Therapeutics. Vol. 6. Amsterdam: North Holland, Publ. Comp., 1977, p 161.
von Ardenne, M., Reitnauer, P. G., Selective occlusion of cancer tissue capillaries as central mechanism of Cancer Multistep Therapy. Jpn. J. Clin. Oncol. 10: 31, 1980.
Song, C. W., Effect of hyperthermia on vascular functions of normal tissue and experimental tumors. J. Natl. Cancer Inst. 60: 711, 1978.
von Ardenne, M., Theoretische und experimentelle Grundlagen der Krebs-Mehrschritt-Therapie. 2nd ed, Berlin: Volk and Gesundheit, 1970/1971.
von Ardenne, M., Prinzipien und Konzept 1974 der Krebs-Mehrschritt-Therapie. Radio Biol., Radiother. 16; 99, 1975.
von Ardenne, M., Prinzipien und Konzept 1977 der Krebs-Mehrschritt-Therapie. Arch Geschwulstforsch 48: 504, 1978.
von Ardenne, M., Über den Entwicklungsstand der Krebs-Mehrschritt-Therapie. Med. in uns Zeit 3: 34, 1979.
Vaupel, P., Ostheimer, K., Muller-Klieser, W. Circulatory and metabolic responses of malignant tumors during localized hyperthermia. J. Cancer Res. Clin. Oncol. 98: 15, 1980.
von Ardenne, M., Reitnauer, P. G., Gewebe-Ubersäuerung und Mikrozirkulation. Arch Geschwulstforsch 48: 729, 1978.
Jain, R. K., Temperature distribution in normal and neoplastic tissues during normothermia and hyperthermia. Ann NY Acad. Sci. 335: 48, 1980.
Vaupel, P., Thews, G., Wendling, P., Kritische Sauerstoff-und Glucoseversorgung maligner Tumoren. Klin Wschr. 101: 1810, 1976.
von Ardenne, M., Vereinfachung der Krebs-Mehrschritt-Therapie durch induzierte Spontanhyperthermie. Krebsgeschehen 8: 26, 1976.
von Ardenne, M., von Ardenne, T., Böhme, G., Dekawellen-Rasterhyperthermie. Ein neues Diathermieverfahren mit homogenisierter Energiezufuhr und sehr hoher Tiefenwirkung in Körpergewebe. Z Physiother. 29: 225, 1977.
von Ardenne, M., On a new physical principle for selective local hyperthermia. in Streffer C. (ed); Cancer Therapy by Hyperthermia and Radiation. Baltimore-Munich, Urban and Schwarzenberg, 1978, p 96.
von Ardenne, M., Böhme, G., Kell, E., Reitnauer, P. G., Die Bedeutung der Warmeleitung für die therapeutischen Grenzen der selektiven Lokalhyperthermie von Krebsgeweben. Arch Geschwulstforsch, 47: 487, 1977.
von Ardenne, M., Bohme, G., Kell, E., On the optimization of local hyperthermy in tumors based on a new radiofrequency procedure. J. Cancer Res. Clin. Oncol. 49: 590, 1979.
von Ardenne, M., Kell, E., Berechnung des dynamischen Aufheiz-prozesses in mehrschichtigen Modellgeweben bei Lokalhyperthermie nach dem CMT-Selektotherm-Verfahren. Arch Geschwulstforsch, 49: 590, 1979.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
von Ardenne, M., Krüger, W. (1982). Recent Trends in the Cancer Multistep Therapy Concept. In: Bicher, H.I., Bruley, D.F. (eds) Hyperthermia. Advances in Experimental Medicine and Biology, vol 157. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4388-2_8
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4388-2_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4390-5
Online ISBN: 978-1-4684-4388-2
eBook Packages: Springer Book Archive