Impact of Localized Microwave Hyperthermia on the Oxygenation Status of Malignant Tumors

  • J. Otte
  • R. Manz
  • G. Thews
  • P. Vaupel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 157)


Considerable insight into the mechanisms of heat induced cell death in vitro has been gained during recent years (for reviews see 1–3). Besides the direct cell killing effect of heat, many microenvironmental or milieu factors seem to play an important role during heat treatment of solid tumors in vivo, such that a preferential effect of hyperthermia on tumors has been postulated for the in situ conditions. Environmental factors affecting the tumor milieu, such as tissue oxygen partial pressures, pH values, glucose (?) and lactate levels, nutrient supply and drainage of wastes, have thus become a subject of topical interest.


Tissue Oxygenation Tissue Temperature Tissue Acidosis Topical Interest Nutritive Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Dickson, J. A., The effects of hyperthermia in animal tumor systems. Rec. Res. Cancer Res. 59, 43, 1977.Google Scholar
  2. 2.
    Overgaard, J., Effect of hyperthermia on malignant cells in vivo. Cancer 39, 2637, 1977.PubMedCrossRefGoogle Scholar
  3. 3.
    Suit, H. D., Hyperthermic effects on animal tissues. Radiology 123, 483, 1977.PubMedGoogle Scholar
  4. 4.
    Gerweck, L. E., Nygaard, T. G., Burlett, M., Response of cells to hyperthermia under acute and chronic hypoxic conditions. Cancer Res. 39, 966, 1979.PubMedGoogle Scholar
  5. 5.
    Overgaard, J., Effect of hyperthermia on the hypoxic fraction in an experimental mammary carcinoma in vivo. Brit. J. Cancer 54, 245, 1981.Google Scholar
  6. 6.
    Gerweck, L. E., Richards, B., Influence of pH on the thermal sensitivity of cultured human glioblastoma cells. Cancer Res. 41, 845, 1981.PubMedGoogle Scholar
  7. 7.
    Vaupel, P., Frinak, S., Müller-Klieser, W., Bicher, H. I., Impact of localized hyperthermia on the cellular micro-environment in solid tumors. J. Nat. Cancer Inst. Mono. 60, in press, 1981.Google Scholar
  8. 8.
    Vaupel, P., Ostheimer, K., Müller-Klieser, W., Circulatory and metabolic responses of malignant tumors during localized hyperthermia. J. Cancer Res. Clin. Oncol. 98, 15, 1980.PubMedCrossRefGoogle Scholar
  9. 9.
    Bicher, H. I., Hetzel, F. W., Sandhu, T. S., Frinak, S., Vaupel, P., O’Hara, M. D., O’Brien, T., Effects of hyperthermia on normal and tumor microenvironment. Radiology 137, 523, 1980.PubMedGoogle Scholar
  10. 10.
    Eddy, H. A., Alterations in tumor microvasculature during hyperthermia. Radiology 137, 515, 1980.PubMedGoogle Scholar
  11. 11.
    Emami, B., Nussbaum, G. H., Hahn, N., Piro, A. J., Dritschilo, A., Quimby, F., Histopathological study on the effect of hyperthermia on microvasculature. Int. J. Radiat. Oncol. Biol. Phys. 7, 343, 1981.PubMedCrossRefGoogle Scholar
  12. 12.
    Grunewald, W. A., Lübbers, D. W., Kryophotometry as a method for analyzing the intracapillary HbO2 saturation of organs under different O2 supply conditions. Adv. exp. Med. Biol. 75, 55, 1976.PubMedGoogle Scholar
  13. 13.
    Vaupel, P., Manz, R., Müller-Klieser, W., Grunewald, W. A., Intracapillary HbO2 saturation in malignant tumors during normoxia and hyperoxia. Microvasc. Res. 17, 181, 1979.PubMedCrossRefGoogle Scholar
  14. 14.
    Muller-Klieser, W., Zander, R., Vaupel, P., Oxygen consumption of tumor cells suspended in native ascitic fluid at 1–42–C. Pflügers Arch. 377, R17, 1978.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • J. Otte
    • 1
    • 2
  • R. Manz
    • 1
    • 2
  • G. Thews
    • 1
    • 2
  • P. Vaupel
    • 1
    • 2
  1. 1.Department of PhysiologyUniversity of RegensburgRegensburgWest Germany
  2. 2.Department of PhysiologyUniversity of MainzMainzWest Germany

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