Impact of Localized Microwave Hyperthermia on the Oxygenation Status of Malignant Tumors
Considerable insight into the mechanisms of heat induced cell death in vitro has been gained during recent years (for reviews see 1–3). Besides the direct cell killing effect of heat, many microenvironmental or milieu factors seem to play an important role during heat treatment of solid tumors in vivo, such that a preferential effect of hyperthermia on tumors has been postulated for the in situ conditions. Environmental factors affecting the tumor milieu, such as tissue oxygen partial pressures, pH values, glucose (?) and lactate levels, nutrient supply and drainage of wastes, have thus become a subject of topical interest.
KeywordsTissue Oxygenation Tissue Temperature Tissue Acidosis Topical Interest Nutritive Blood Flow
Unable to display preview. Download preview PDF.
- 1.Dickson, J. A., The effects of hyperthermia in animal tumor systems. Rec. Res. Cancer Res. 59, 43, 1977.Google Scholar
- 5.Overgaard, J., Effect of hyperthermia on the hypoxic fraction in an experimental mammary carcinoma in vivo. Brit. J. Cancer 54, 245, 1981.Google Scholar
- 7.Vaupel, P., Frinak, S., Müller-Klieser, W., Bicher, H. I., Impact of localized hyperthermia on the cellular micro-environment in solid tumors. J. Nat. Cancer Inst. Mono. 60, in press, 1981.Google Scholar
- 14.Muller-Klieser, W., Zander, R., Vaupel, P., Oxygen consumption of tumor cells suspended in native ascitic fluid at 1–42–C. Pflügers Arch. 377, R17, 1978.Google Scholar