Effects of Hyperthermia and Hyperglycemia on the Metastases Formation and on Survival of Rat Bearing W256 Carcinosarcoma

  • Sudhir A. Shah
  • Rakesh K. Jain
  • Pamela L. Finney
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 157)

Abstract

The selective destructive effect of hyperthermia (temperatures ≥ 42°C) on a variety of malignant tumors in animals is now well documented, and there is increasing evidence that many of the findings in animal tumor systems apply to human cancer (see Milder, 1979; Jain and Gullino, 1980). Current thrust in this field is directed towards defining the place of hyperthermia in human cancer therapy, and advance in this direction depends upon determining how best to apply and control the heat, as well as understanding more about its mechanism of action. It has been suspected for a long time that the interplay of various physiological factors (e.g. cell pH, tumor blood flow and the host immune system) other than the degree of physical heat applied may determine the outcome for a tumor treated by hyperthermia in vivo. Results to date indicate that tumors fall into two zones of thermal sensitivity, 42–43°C and 45–50°C. Most human tumors are not sensitive to 42–43°C temperature range (see Dickson and Shah, 1977), and temperatures greater than 42°C for prolonged periods can cause irreversible damage to normal surrounding tissues. Also, due to physiological limitations, disseminated disease cannot be treated by whole-body hyperthermia in the higher temperature zone. Therefore, effective treatment of cancer by hyperthermia would depend on selectively heating the tumor by manipulating tumor blood flow and by using potentiators of hyperthermia.

Keywords

Microwave Lactate Cage Respiration Melphalan 

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Sudhir A. Shah
    • 1
  • Rakesh K. Jain
    • 1
  • Pamela L. Finney
    • 1
  1. 1.Cancer Research Laboratory, Department of Chemical EngineeringCarnegie-Mellon UniversityPittsburghUSA

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