Microfilament Dysfunction in Cholestasis: Possible Involvement in Familial Pediatric Cholestatic Syndromes

  • A. Weber
  • I. Yousef
  • B. Tuchweber
Part of the Hepatology book series (H, volume 5)


During the last decade, increased interest in cholestasis has developed, which can be explained by the recent advances made in the knowledge of factors involved in bile formation and/or secretion (1). Recently the known concepts in muscle cell biology have been applied to the hepatocyte, drawing attention to the cytoskeleton, a highly elaborate system of proteins that regulates structure and motility, and probably participates in the dynamic process of bile flow (2). A broader definition of cholestasis has also been proposed which is supposed to please physiologists, morphologists, clinical biochemists and clinicians. Indeed cholestasis does no longer only imply jaundice, but, in the absence of extrahepatic biliary obstruction, it might be defined as a primary disturbance in hepatic bile formation (3). This includes the conditions of “bilirubinostasis” as well as those associated with reduced bile flow where excretion of bile salts is primarily defective (4).


Biliary Atresia Bile Flow Intrahepatic Cholestasis Bile Canaliculus Canalicular Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • A. Weber
    • 1
  • I. Yousef
    • 1
  • B. Tuchweber
    • 1
  1. 1.Départements de Pédiatrie, Pathologie et NutritionUniversité de MontréalMontréalCanada

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