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The Role of Bile Acids in Pediatric Cholestasis

  • Harvey L. Sharp
  • Deborah K. Freese
  • Russell F. Hanson
Part of the Hepatology book series (H, volume 5)

Abstract

Bile acid metabolism is clearly altered by liver disease. The converse, however, as to whether bile acids contribute to the pathogenesis of liver disease is cloudy. Hepatobiliary disease will result from the administration of bile acids, particularly lithocholic acid, to lower animal species. Does a human counterpart exist? This chapter reexamines the role of bile acids in cholestasis by considering four areas: 1) physiological cholestasis of the newborn; 2) bile acid related cholestasis; 3) inborn errors of bile acid metabolism; and 4) our results with medical therapy in pediatric cholestatic conditions.

Keywords

Bile Acid Bile Salt Biliary Atresia Cholic Acid Intrahepatic Bile Duct 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Harvey L. Sharp
    • 1
  • Deborah K. Freese
    • 1
  • Russell F. Hanson
    • 1
  1. 1.Departments of Pediatrics and MedicineUniversity of Minnesota Health Sciences CenterMinneapolisUSA

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