The Role of Bile Acids in Pediatric Cholestasis

  • Harvey L. Sharp
  • Deborah K. Freese
  • Russell F. Hanson
Part of the Hepatology book series (H, volume 5)


Bile acid metabolism is clearly altered by liver disease. The converse, however, as to whether bile acids contribute to the pathogenesis of liver disease is cloudy. Hepatobiliary disease will result from the administration of bile acids, particularly lithocholic acid, to lower animal species. Does a human counterpart exist? This chapter reexamines the role of bile acids in cholestasis by considering four areas: 1) physiological cholestasis of the newborn; 2) bile acid related cholestasis; 3) inborn errors of bile acid metabolism; and 4) our results with medical therapy in pediatric cholestatic conditions.


Bile Acid Bile Salt Biliary Atresia Cholic Acid Intrahepatic Bile Duct 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Harvey L. Sharp
    • 1
  • Deborah K. Freese
    • 1
  • Russell F. Hanson
    • 1
  1. 1.Departments of Pediatrics and MedicineUniversity of Minnesota Health Sciences CenterMinneapolisUSA

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