Hepatic Drug-Metabolizing Enzymes during Embryonic and Fetal Development

  • Allan B. Okey
  • Daniėl Nebert
Part of the Hepatology book series (H, volume 5)


Twenty or thirty years ago, it was believed that all drugs (and other environmental pollutants) were “toxic”, or pharmacologically active, in their parent (non-metabolized) form. The function of all drug-metabolizing enzymes was therefore regarded as detoxication, i.e. to “inactivate” the active parent drug. More recently it has become increasingly evident that although some drugs are, indeed, active in their nonmetabolized parent form, many drugs are inactive until being metabolized (1,2). A delicate balance exists, therefore, between detoxication and toxification.


Sister Chromatid Exchange Slow Acetylators Monooxygenase Activity Polycyclic Hydrocarbon Polycyclic Aromatic Compound 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Allan B. Okey
    • 1
    • 2
  • Daniėl Nebert
    • 1
    • 2
  1. 1.Division of Clinical Pharmacology, Dept. PaediatricsThe Hospital for Sick ChildrenTorontoCanada
  2. 2.Developmental Pharmacology BranchNational Institute of Child Health and Human Development, National Institutes of HealthBethesdaUSA

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