Developmental Aspects of Bile Acid Metabolism and Hepatic Function

  • John B. Watkins
Part of the Hepatology book series (H, volume 5)


Bile acids represent the major solid constituents in bile. They are essential for bile formation due principally to their unique chemical and structural characteristics which permit the solubilization and secretion of nonpolar lipids and potentially toxic compounds into bile. In the fetus and developing infant, major changes in the structural and functional characteristics of the hepatocytes and in the organization of the liver occur. In turn, biliary lipid secretion, the distribution and size of the bile acid pool and the functional capacity of the infant to excrete organic anions and absorb essential lipophilic nutrients are markedly altered.


Bile Acid Cholic Acid Enterohepatic Circulation Bile Acid Synthesis Lithocholic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • John B. Watkins
    • 1
    • 2
  1. 1.Department of PediatricsUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Division of Gastroenterology and NutritionThe Children’s Hospital of PhiladelphiaPhiladelphiaPennsylvaniaUSA

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