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Viral Hepatitis Type A: Redefinition of Virologic, Clinical and Epidemiologic Features

  • Jules L. Dienstag
Part of the Hepatology book series (H, volume 5)

Abstract

During the last decade, hepatitis A research has accelerated dramatically. Until the early 1970’s, no practical serologic tests were available to identify hepatitis A infection, and investigative tools were limited. Still, painstaking epidemiologic observations and experimental transmission of the virus in volunteers (1,2) and marmoset monkeys (3–6) provided the foundations for the advances of recent years. Such studies had shown that hepatitis A virus (HAV) is excreted in feces during the late incubation period and early acute phase of illness and that convalescent serum (as well as immune serum globulin) contains neutralizing antibodies to HAV. Based on these studies, Feinstone et al (7) incubated convalescent serum, likely to contain antibody to HAV (anti-HAV), with filtrates of acute phase stool specimens, likely to contain HAV and, by electron microscopy, visualized HAV particles aggregated by antibody (immune electron microscopy). At the same time, almost a decade of work on experimental HAV infection in marmosets culminated in the detection by Provost et al (8) of virus-like particles morphologically similar to those described in human stools in homogenates and thin-section electron micrographs of liver and in concentrated serum of Saguinus mystax marmosets infected experimentally with the CR326 strain of HAV.

Keywords

Fulminant Hepatitis Indian Childhood Cirrhosis Immune Electron Microscopy Immune Serum Globulin Viral Hepatitis Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Jules L. Dienstag
    • 1
    • 2
  1. 1.Gastrointestinal Unit (Medical Services)Massachusetts General HospitalUSA
  2. 2.Department of MedicineHarvard Medical SchoolBostonUSA

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