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Regulation and Function of Cellular Gene Products Involved in UV and Chemical Mutagenesis in E. Coli

  • Graham C. Walker
  • Stephen J. Elledge
  • Karen L. Perry
  • Anne Bagg
  • Cynthia J. Kenyon
Part of the Basic Life Sciences book series (volume 15)

Abstract

The past few years have seen a remarkable increase in our understanding of the strategies employed by cells in dealing with damage to their genetic material. Of particular interest has been the recognition that mutagenesis by a variety of agents including UV, methyl methanesulfonate (MMS), and 4-nitroquinoline-1-oxide (NQO) is not a passive process. Rather it requires the intervention of a cellular system which processes damaged DNA in such a way that mutations result. Mutagenesis is not a necessary consequence of DNA damage since, if this system is inactivated, no mutations result. In this paper we would like to summarize some of the recent work of our lab on the cellular molecular mechanisms involved in UV and chemical mutagenesis.

Keywords

Chemical Mutagenesis Spontaneous Mutation Rate lexA Protein Apurinic Site Phage Survival 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Graham C. Walker
    • 1
  • Stephen J. Elledge
    • 1
  • Karen L. Perry
    • 1
  • Anne Bagg
    • 1
  • Cynthia J. Kenyon
    • 1
  1. 1.Biology DepartmentMassachusetts Institute of TechnologyCambridgeUSA

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