Analysis of Chemically Induced Mutation in Single Cell Populations
This discussion is about tools to analyze the complex relationship between chemicals and mutation in a relatively simple biological system: the exponentially growing single cell population. Three assumptions are made about this relationship: that some DNA adducts are premutagenic lesions, that adducted DNA may be repaired, misrepaired or unrepaired at the time of DNA synthesis and that unrepaired DNA may be replicated, misreplicated or unreplicated at the time of mitosis. These three assumptions lead to the definition of variables ascertainable by experimental measurement which, in turn, lead to explicit formulae which should be useful as guides in the analysis of dose(adduct) -response(mutation) relations.
KeywordsRepair System Progression Effect Human Lymphoblast Host Cell Reactivation Single Cell Population
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