Mutagenic Effects of Nucleic Acid Modification and Repair Assessed by in Vitro Transcription

  • B. Singer
Part of the Basic Life Sciences book series (volume 15)


Mutagenesis is defined as a heritable change which can occur through indirect as well as direct change in the genetic message. This paper, however, will focus on the direct effects of chemical modification of nucleic acids. Since man is the species we are most concerned about, the effect of modification on mammalian cells or whole animals will be stressed whenever possible.


Nucleic Acid Alkylating Agent Vinyl Chloride Alkyl Sulfate Tautomeric Equilibrium 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • B. Singer
    • 1
  1. 1.Department of Molecular Biology and Virus LaboratoryUniversity of CaliforniaBerkeleyUSA

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