Cell Density Mediated Changes in Cyclic AMP Phosphodiesterase Activity during Cell Differentiation in Moss

  • S. Sharma
  • M. M. Johri
Part of the Basic Life Sciences book series (BLSC, volume 22)


Cyclic 3′,5′-adenosine monophosphate (cAMP) enhances the differentiation of chloronema cell type in the protonema cultures of the moss Funaria hygrometrica (1, 2). The endogenous level of cAMP is 4- to 7-fold higher in chloronema cells than that in caulonema cells (1). Thus there is a reduction in the cAMP level during caulonema differentiation. This could involve a modulation of adenylate cyclase and/or cAMP phosphodiesterase activity. Since the initiation of caulonema differentiation (3), and the activity of cAMP phosphodiesterase (4) depend on the amount of inoculum, we have investigated cell-density-mediated changes in cAMP phosphodiesterase activity in relation to caulonema differentiation.


Spend Medium Phosphodiesterase Activity cAMP Phosphodiesterase Wild Type Cell Line Moss Protonema 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • S. Sharma
    • 1
  • M. M. Johri
    • 1
  1. 1.Molecular Biology UnitTata Institute of Fundamental ResearchBombayIndia

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