Advertisement

Glycine

  • E. C. Daly
  • M. H. Aprison

Abstract

Glycine is structurally the simplest amino acid and is found in all body fluids and proteinaceous tissue in relatively large amounts. Although glycine is a nonessential amino acid, it is an essential intermediate in the metabolism of protein, peptides, one-carbon fragments, nucleic acids, porphyrins, and bile salts. In addition, within the last 20 years a neurotransmitter role for glycine has been recognized within the CNS.1 Subsequent neurochemical investigations have attempted to separate the “general metabolic” and “transmitter” functions of glycine within the CNS.

Keywords

Spinal Cord Glycine Receptor Tetanus Toxin Glycine Cleavage System Glycine Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Aprison, M. H., and Werman, R., 1965, Life Sci. 4: 2075–2083.PubMedCrossRefGoogle Scholar
  2. 2.
    Aprison, M. H., and Werman, R., 1968, Neurosci. Res. 1: 143–174.PubMedGoogle Scholar
  3. 3.
    Werman, R., and Aprison, M. H., 1968, Structure and Function of Inhibitory Neuronal Mechanisms (C. von Euler, S. Skogland, and U. Soderberg, eds.), Pergamon Press, New York, pp. 473–486.Google Scholar
  4. 4.
    Eecles, J. C., 1964, The Physiology of Synapses, Springer-Verlag, Berlin.CrossRefGoogle Scholar
  5. 5.
    Curtis, D. R., and Watkins, J. C., 1960, J. Neurochem. 6: 117–141.PubMedCrossRefGoogle Scholar
  6. 6.
    Curtis, D. R., 1963, Pharmacol. Rev. 15: 333–364.PubMedGoogle Scholar
  7. 7.
    Krnjevic, K., 1974, Physiol. Rev. 54: 418–540.Google Scholar
  8. 8.
    Curtis, D. R., and Johnston, G. A. R., 1974, Ergeb. Physiol. Biol. Chem. Pharmakol. 69: 97–188.Google Scholar
  9. 9.
    Aprison, M. H., and Daly, E. C., 1978, Adv. Neurochem. 3: 203–294.CrossRefGoogle Scholar
  10. 10.
    Pyeock, C. J., and Kerwin, R. W., 1981, Life Sci. 28: 2679–2686.CrossRefGoogle Scholar
  11. 11.
    Lapin, A., and Karobath, M., 1980, J. Chromatogr. 193: 95–99.PubMedCrossRefGoogle Scholar
  12. 12.
    Fernstrom, M. H., and Fernstrom, J. D., 1981, Life Sci. 29: 2119–2130.PubMedCrossRefGoogle Scholar
  13. 13.
    Shank, R. P., and Aprison, M. H., 1970, Anal. Biochem. 35: 136–145.PubMedCrossRefGoogle Scholar
  14. 14.
    Briel, G., and Neuhoff, V., 1972, Hoppe Seylers Z. Physiol Chem. 353: 540–553.PubMedCrossRefGoogle Scholar
  15. 15.
    Aprison, M. H., and Shank, R. P., 1970, Exp. Physiol. Biochem. 3: 31–38.Google Scholar
  16. 16.
    Sardesai, V. M., and Provido, H. S., 1970, Clin. Chim. Acta 29: 67–71.PubMedCrossRefGoogle Scholar
  17. 17.
    Goodwin, J. F., and Stampwala, S., 1973, Clin. Chem. 19: 1010–1015.PubMedGoogle Scholar
  18. 18.
    Ohmori, S., Ikeda, M., Watanabe, Y., and Hirota, K., 1970, Anal. Biochem. 90: 662–670.CrossRefGoogle Scholar
  19. 19.
    Frazier, P. D., and Summer, G. K., 1971, Anal. Biochem. 44: 66–76.PubMedCrossRefGoogle Scholar
  20. 20.
    Berger, S. J., Carter, J., G., and Lowry, O. H., 1975, Anal. Biochem. 65: 232–240.PubMedCrossRefGoogle Scholar
  21. 21.
    Cutler, R. W. P., and Dudzinski, D. S., 1974, J. Neurochem. 23: 1005–1009.PubMedCrossRefGoogle Scholar
  22. 22.
    Davies, L. P., and Johnston, G. A. R., 1974, J. Neurochem. 22: 107–112.PubMedCrossRefGoogle Scholar
  23. 23.
    Lajtha, A., and Toth, J., 1973, Brain Res. 55: 238–241.PubMedCrossRefGoogle Scholar
  24. 24.
    Agrawal, H. C., and Himwich, W. A., 1970, Developmental Neurobiology (W. A. Himwich, ed.), Charles C Thomas, Springfield, Illinois, pp. 287–310.Google Scholar
  25. 25.
    Piepho, R. W., and Freidman, A. H., 1971, Life Sci. 10: 1355–1362.CrossRefGoogle Scholar
  26. 26.
    Ross, F. H., Sermons, A. L., and Walker, C. W., 1980, Life Sci. 26: 1019–1022.PubMedCrossRefGoogle Scholar
  27. 27.
    Ross, F. H., Sermons, A. L., Owasoyo, J. O., and Walker, C. W., 1980, Pharmacol. Res. Commun. 12: 891–897.PubMedCrossRefGoogle Scholar
  28. 28.
    Shank, R. P., and Aprison, M. H., 1970, J. Neurochem. 17: 1461–1475.PubMedCrossRefGoogle Scholar
  29. 29.
    Fernstrom, J. D., Larin, F., and Wurtman, R. J., 1971, Life Sci. 10: 813–819.CrossRefGoogle Scholar
  30. 30.
    Shank, R. P., and Aprison, M. H., 1971, J. Neurobiol. 2: 145–151.PubMedCrossRefGoogle Scholar
  31. 31.
    Lajtha, A., and Toth, J., 1974, Brain Res. 76: 546–551.PubMedCrossRefGoogle Scholar
  32. 32.
    Perry, T. L., Hansen, S., and Gandham, S. S., 1981, J. Neurochem. 36: 406–412.PubMedCrossRefGoogle Scholar
  33. 33.
    Graham, L. T., Jr., Shank, R. P., Werman, R., and Aprison, M. H., 1967, J. Neurochem. 14: 465–572.PubMedCrossRefGoogle Scholar
  34. 34.
    Aprison, M. H., Shank, R. P., and Davidoff, R. A., 1969, Comp. Biochem. Physiol. 28: 1345–1355.PubMedCrossRefGoogle Scholar
  35. 35.
    Davidoff, R. A., Graham, L. T., Jr., Shank, R. P., Werman, R., and Aprison, M. H., 1967, J. Neurochem. 14: 1025–1031.PubMedCrossRefGoogle Scholar
  36. 36.
    Homma, S., Suzuki, T., Murayama, S., and Otsuka, M., 1979, J. Neurochem. 32: 691–698.PubMedCrossRefGoogle Scholar
  37. 37.
    Miyata, Y., and Otsuka, M., 1975, J. Neurochem. 25: 239–244.PubMedCrossRefGoogle Scholar
  38. 38.
    Johnston, G. A. R., 1968, J. Neurochem. 15: 1013–1017.PubMedCrossRefGoogle Scholar
  39. 39.
    Boehme, D. H., Fordice, M. W., Marks, N., and Vogel, W., 1973, Brain Res. 50: 353–359.PubMedCrossRefGoogle Scholar
  40. 40.
    Berger, S. J., Carter, J. G., and Lowry, O. H., 1977, J. Neurochem. 28: 149–158.PubMedCrossRefGoogle Scholar
  41. 41.
    Roberts, F., and Hill, R. G., 1978, J. Neurochem. 31: 1549–1551.PubMedCrossRefGoogle Scholar
  42. 42.
    Adams, J. C., and Wenthold, R. J., 1979, Neuroscience 4: 1947–1951.PubMedCrossRefGoogle Scholar
  43. 43.
    James, T. A., and Starr, M. S., 1979, Eur. J. Pharmaco. 57: 115–125.Google Scholar
  44. 44.
    Godfrey, D. A., Carter, J. G., Lowry, O. H., and Matschinsky, F., 1978, J. Histochem. Cytochem. 26: 118–126.PubMedCrossRefGoogle Scholar
  45. 45.
    Shaw, R. K., and Heine, J. D., 1965, J. Neurochem. 12: 151–155.PubMedCrossRefGoogle Scholar
  46. 46.
    Cohen, A. I., McDaniel, M., and Orr, H., 1973, Invest. Ophthalmol. 12: 686–693.PubMedGoogle Scholar
  47. 47.
    Kennedy, A. J., Neal, M. J., and Lolley, R. N., 1977, J. Neurochem. 29: 157–159.PubMedCrossRefGoogle Scholar
  48. 48.
    Berger, S. J., McDaniel, M. L., Carter, J. G., and Lowry, O. H., 1977, J. Neurochem. 28:159- 163.Google Scholar
  49. 49.
    Serra, S., Grynbaum, A., Lajtha, A., and Marks, N., 1972, Brain Res. 44: 579–592.PubMedCrossRefGoogle Scholar
  50. 50.
    Osborne, R. H., Bradford, H. F., and Jones, D. G., 1973, J. Neurochem. 21: 407–419.PubMedCrossRefGoogle Scholar
  51. 51.
    Bradford, H. F., Bennett, G. W., and Thomas, A. J., 1973, J. Neurochem. 21: 495–505.PubMedCrossRefGoogle Scholar
  52. 52.
    Kontro, P., Marnela, K.-M., and Oja, S. S., 1980, Brain Res. 184: 129–141.PubMedCrossRefGoogle Scholar
  53. 53.
    DeBelleroche, J. S., and Bradford, H. F., 1973, J. Neurochem. 21: 441–451.CrossRefGoogle Scholar
  54. 54.
    McBride, W. J., Daly, E., and Aprison, M. H., 1973, J. Neurobiol. 4: 557–566.PubMedCrossRefGoogle Scholar
  55. 55.
    Fonnum, F., and Walberg, F., 1973, Brain Res. 62: 577–579.PubMedCrossRefGoogle Scholar
  56. 56.
    Aprison, M. H., Daly, E. C., Shank, R. P., and McBride, W. J., 1975, Metabolic Compartmentation and Neurotransmission (S. Berl, D. D. Clarke, and D. Schneider, eds.), Plenum Press, New York, pp. 37–63.CrossRefGoogle Scholar
  57. 57.
    DeBelleroche, J. S., and Bradford, H. F., 1977, J. Neurochem. 29: 335–343.CrossRefGoogle Scholar
  58. 58.
    Iliffe, T. M. McAdoo, D. J., Beyer, C. B., and Haber, B., 1977, J. Neurochem. 28: 1037–1042.PubMedCrossRefGoogle Scholar
  59. 59.
    Price, C. H., Goggeshall, R. E., and McAdoo, D. J., 1978, Brain Res. 154: 25–40.PubMedCrossRefGoogle Scholar
  60. 60.
    Price, C. H., McAdoo, D. J., Fair, W., and Okura, E. R., 1979, J. Neurobiol 10: 551–571.PubMedCrossRefGoogle Scholar
  61. 61.
    Sawadra, M., McAdoo, D. J., Blankovship, J. E., and Price, C. H., 1981,BrainRes. 207: 486–490.CrossRefGoogle Scholar
  62. 62.
    Price, C. H., and McAdoo, D. J., 1981, Brain Res. 219: 307–315.PubMedCrossRefGoogle Scholar
  63. 63.
    Banos, G., Daniel, P. M., Moorhouse, S. R., and Pratt, O. E., 1975, J. Physiol (Lond.) 246: 539–548.Google Scholar
  64. 64.
    Oldendorf, W. H., and Szabo, J., 1976, Am. J. Physiol. 230: 94–98.PubMedGoogle Scholar
  65. 65.
    Battistin, L., Grynbaum, A., and Lajtha, A., 1971, Brain Res. 29: 85–99.PubMedCrossRefGoogle Scholar
  66. 66.
    Toth, E., and Lajtha, A., 1981, Trans. Am. Soc. Neurochem. 12: 158.Google Scholar
  67. 67.
    Banos, G., Daniel, P. M., Moorhouse, S. R., and Pratt, O. E., 1971, J. Physiol. (Lond.) 213: 45P–46 P.Google Scholar
  68. 68.
    Seta, K., Sershen, H., and Lajtha, A., 1972, Brain Res. 47: 415–425.PubMedCrossRefGoogle Scholar
  69. 69.
    O’Fallon, J. V., and Brosemer, R. W., 1978, J. Neurochem. 31: 365–366.PubMedCrossRefGoogle Scholar
  70. 70.
    Bridgers, W. F., 1965, J. Biol. Chem. 240: 4591–4597.PubMedGoogle Scholar
  71. 71.
    Uhr, M. L., and Sneddon, M. K., 1972, J. Neurochem. 19: 1495–1500.PubMedCrossRefGoogle Scholar
  72. 72.
    Feld, R. D., and Sallach, H. J., 1974, Brain Res. 73: 558–562.PubMedCrossRefGoogle Scholar
  73. 73.
    Hedrick, J. L., and Sallach, H. J., 1964, Arch. Biochem. Biophys. 105: 261–269.PubMedCrossRefGoogle Scholar
  74. 74.
    Kondrashova, M. N., and Rodlonova, M. A., 1971, Dokl. Akad. Nauk SSSR 196: 1225–1227.PubMedGoogle Scholar
  75. 75.
    DeMarchi, W. J., and Johnston, G. A. R., 1969, J. Neurochem. 16: 355–361.CrossRefGoogle Scholar
  76. 76.
    Gaunt, G. L., and DeDuve, C., 1976, J. Neurochem. 26: 749–759.PubMedCrossRefGoogle Scholar
  77. 77.
    Arnold, G., Liscum, L., and Holtzman, E., 1979, J. Histochem. Cytochem. 27: 735–745.PubMedCrossRefGoogle Scholar
  78. 78.
    Shank, R. P., Aprison, M. H., and Baxter, C. F., 1973, Brain Res. 52: 301–308.PubMedCrossRefGoogle Scholar
  79. 79.
    Maher, T. J., and Wurtman, R. J., 1980, Life Sci. 26: 1283–1286.PubMedCrossRefGoogle Scholar
  80. 80.
    Siemers, E. R., Daly, E. C., and Aprison, M. H., 1980, Trans. Am. Soc. Neurochem. 11: 69.Google Scholar
  81. 81.
    Bird, M. I., and Nunn, P. B., 1979, Biochem. Soc. Trans. 7: 1276–1277.PubMedGoogle Scholar
  82. 82.
    Sky-Peck, H. H., Rosenbloom, C., and Winzler, R. J., 1966, J. Neurochem. 13: 223–228.PubMedCrossRefGoogle Scholar
  83. 83.
    Bridgers, W. F., 1968, J. Neurochem. 15: 1325–1328.PubMedCrossRefGoogle Scholar
  84. 84.
    Ordonez, L. A., and Wurtman, R. J., 1973, J. Neurochem. 21: 1447–1455.PubMedCrossRefGoogle Scholar
  85. 85.
    Broderick, D. S., Candland, K. L., North, J. A., and Mangum, J. H., 1972, Arch. Biochem. Biophys. 148: 196–198.PubMedCrossRefGoogle Scholar
  86. 86.
    Davies, L. P., and Johnston, G. A. R., 1973, Brain Res. 54: 149–156.CrossRefGoogle Scholar
  87. 87.
    Daly, E. C., and Aprison, M. H., 1974, J. Neurochem. 22: 877–885.PubMedCrossRefGoogle Scholar
  88. 88.
    McClain, L. D., Carl, G. F., and Bridgers, W. F., 1975, J. Neurochem. 24: 719–722.PubMedGoogle Scholar
  89. 89.
    Rassin, D. K., and Gaull, G. E., 1975, J. Neurochem. 24: 969–978.PubMedCrossRefGoogle Scholar
  90. 90.
    DeRobertis, E., Pellegrino Delraldi, A., Rodriquez DeLores Arnaiz, G., and Salganicoff, L., 1962, J. Neurochem. 9: 23–35.Google Scholar
  91. 91.
    Burton, E. G., and Sallach, H. J., 1975, Arch. Biochem. Biophys. 166: 483–494.PubMedCrossRefGoogle Scholar
  92. 92.
    Yoshida, T., and Kikuchi, G., 1973, J. Biochem. 73: 1013–1022.PubMedGoogle Scholar
  93. 93.
    Rassin, D. K., Sturman, J. A., and Gaull, G. E., 1981, J. Neurochem. 36: 1263–1271.PubMedCrossRefGoogle Scholar
  94. 94.
    Nakano, Y., Fujioka, M., and Wada, H., 1968, Biochim. Biophys. Acta 159: 19–26.PubMedCrossRefGoogle Scholar
  95. 95.
    Ogawa, H., and Fujioka, M., 1981, J. Biochem. 90: 381–390.PubMedGoogle Scholar
  96. 96.
    Gaull, G. E., VonBerg, W., Raiha, N. C. R., and Sturman, J. A., 1973, Pediatr. Res. 7: 527–533.PubMedCrossRefGoogle Scholar
  97. 97.
    Snell, K., 1980, Biochem. J. 190: 451–455.PubMedGoogle Scholar
  98. 98.
    Suleiman, S. A., and Spector, R., 1982, J. Neurochem. 38: 392–396.PubMedCrossRefGoogle Scholar
  99. 99.
    Johnston, G. A. R., and Vitali, M. V., 1969, Brain Res. 12: 471–472.PubMedCrossRefGoogle Scholar
  100. 100.
    Johnston, G. A. R., and Vitali, M. V., 1969, Brain Res. 15: 201–208.PubMedCrossRefGoogle Scholar
  101. 101.
    Johnston, G. A. R., Vitali, M. V., and Alexander, H. M., 1970, Brain Res. 20: 361–367.PubMedCrossRefGoogle Scholar
  102. 102.
    Benuck, M., Stern, F., and Lajtha, A., 1972, J. Neurochem. 19: 949–957.PubMedCrossRefGoogle Scholar
  103. 103.
    Benuck, M., Stern, F., and Lajtha, A., 1971, J. Neurochem. 18: 1555–1567.PubMedCrossRefGoogle Scholar
  104. 104.
    Dasgupta, P., and Narayanaswami, A., 1981, J. Neurochem. 37: 1603–1606.PubMedCrossRefGoogle Scholar
  105. 105.
    Liang, C.-C., 1962, Biochem. J. 82: 429–434.PubMedGoogle Scholar
  106. 106.
    Steward, C. B., Grammer, J., and Brosemer, R. W., 1981, Ann. Nutr. Metab. 25: 289–298.CrossRefGoogle Scholar
  107. 107.
    Dennis, M. L, and Clarke, J. T. R., 1979, J. Neurochem. 33: 383–385.PubMedCrossRefGoogle Scholar
  108. 108.
    Kikuchi, G., 1973, Mol. Cell Biochem. 1: 169–187.PubMedCrossRefGoogle Scholar
  109. 109.
    Motokawa, Y., and Kikuchi, G., 1971, Arch. Biochem. Biophys. 146: 461–466.PubMedCrossRefGoogle Scholar
  110. 110.
    Bruin, W. J., Frantz, B. M., and Sallach, H. J., 1973, J. Neurochem. 20: 1649–1658.PubMedCrossRefGoogle Scholar
  111. 111.
    Uhr, M. L., 1973, J. Neurochem. 20: 1005–1009.PubMedCrossRefGoogle Scholar
  112. 112.
    Daly, E. C., Nadi, N. S., and Aprison, M. H., 1976, Neurochem. 26: 179–185.Google Scholar
  113. 113.
    Lahoya, J. L., Benavides, J., and Ugarte, M., 1980, Dev. Neurosci. 3: 75–80.PubMedCrossRefGoogle Scholar
  114. 114.
    Herbert, V., and Zalusky, R., 1961, Fed. Proc. 20: 453.Google Scholar
  115. 115.
    Reynolds, E. H., 1976, Clin. Haematol. 5: 661–696.PubMedGoogle Scholar
  116. 116.
    Levitt, M., Nixon, P. F., Pincus, J. H., and Bertino, J. R., 1971, J. Clin. Invest. 50: 1301–1308.PubMedCrossRefGoogle Scholar
  117. 117.
    Fehling, C., Jagerstad, M., Lindstrand, K., and Elmquist, D., 1976, Z. Ernahrungswiss. 15: 1–8.PubMedCrossRefGoogle Scholar
  118. 118.
    Bridgers, W. F., and McClain, L. D., 1972, Adv. Biochem. Psychopharmacol. 4: 81–92.PubMedGoogle Scholar
  119. 119.
    Wang, F. K., Koch, J., and Stokstad, E. L. R., 1967, Biochem. Z. 346: 458–466.PubMedGoogle Scholar
  120. 120.
    Brody, T., Shin, Y. S., and Stokstad, E. L. R., 1976, J. Neurochem. 27: 409–413.PubMedCrossRefGoogle Scholar
  121. 121.
    Shin, Y. S., Williams, M. A., and Stokstad, E. L. R., 1972, Biochem. Biophys. Res. Commun. 47: 35–43.PubMedCrossRefGoogle Scholar
  122. 122.
    Carl, G. F., Peterson, J. D., McClain, L. D., and Bridgers, W. F., 1980, J. Neurochem. 34: 1442–1452.PubMedCrossRefGoogle Scholar
  123. 123.
    Cybulski, R. L., and Fisher, R. R., 1976, Biochemistry 15: 3183–3187.PubMedCrossRefGoogle Scholar
  124. 124.
    Cybulski, R. L., and Fisher, R. R., 1977, Biochemistry 16: 5116–5120.PubMedCrossRefGoogle Scholar
  125. 125.
    Cybulski, R. L., and Fisher, R. R., 1981, Biochim. Biophys. Acta 646: 329–333.PubMedCrossRefGoogle Scholar
  126. 126.
    Rapoport, S., Mueller, M., Dumdey, R., and Rashman, J., 1980, Eur. J. Biochem. 108: 449–455.PubMedCrossRefGoogle Scholar
  127. 127.
    Benavides, J., Garcia, M. L., Lopez-Lahoya, J., Ugarte, M., and Valdiviejo, F., 1980, Biochim. Biophys. Acta 598: 588–594.PubMedCrossRefGoogle Scholar
  128. 128.
    Ordonez, L. A., and Villarroel, H., 1976, J. Neurochem. 27: 305–307.PubMedCrossRefGoogle Scholar
  129. 129.
    Spector, R., Levy, P., and Abelson, H. T., 1977, J. Neurochem. 29: 919–921.PubMedCrossRefGoogle Scholar
  130. 130.
    McClain, L. D., and Bridgers, W. F., 1970, J. Neurochem. 17: 763–766.PubMedCrossRefGoogle Scholar
  131. 131.
    Fuller, R. W., 1976, Life Sci. 19: 625–628.PubMedCrossRefGoogle Scholar
  132. 132.
    Turner, A. J., 1977, Biochem. Pharmacol. 26: 1009–1014.PubMedCrossRefGoogle Scholar
  133. 133.
    Werman, R., Davidoff, R. A., and Aprison, M. H., 1968, J. Neurophysiol. 31: 81–95.PubMedGoogle Scholar
  134. 134.
    Curtis, D. R., Hosli, L. Johnston, G. A. R., and Johnston, I. H., 1968, Exp. Brain Res. 5: 235–258.PubMedCrossRefGoogle Scholar
  135. 135.
    Curtis, D. R., Hosli, L., and Johnston, G. A. R., 1968, Exp. Brain Res. 6: 1–18.PubMedCrossRefGoogle Scholar
  136. 136.
    Krnjevic, K., Puil, E., and Werman, R., 1977, Can. J. Physiol. Pharmacol. 55: 658–669.PubMedCrossRefGoogle Scholar
  137. 137.
    Ryall, R. W., and DeGroat, W. C., 1972, Brain Res. 37: 345–347.PubMedCrossRefGoogle Scholar
  138. 138.
    Game, C. J. A., and Lodge, D., 1975, Exp. Brain Res. 23: 75–84.PubMedCrossRefGoogle Scholar
  139. 139.
    Johnston, S. E., and Davies, J., 1981, Neurosci. Lett. 26: 43–47.PubMedCrossRefGoogle Scholar
  140. 140.
    Biscoe, T. J., Duggan, A. W., and Lodge, D., 1972, Comp. Gen. Pharmacol. 3: 423–433.PubMedCrossRefGoogle Scholar
  141. 141.
    Hosli, L., Hosli, E., and Andres, P. F., 1973, Brain Res. 62: 597–602.PubMedCrossRefGoogle Scholar
  142. 142.
    Obata, K., Oide, M., and Tanaka, H., 1978, Brain Res. 144: 179–184.PubMedCrossRefGoogle Scholar
  143. 143.
    Kelly, J. S., and Renaud, L. P., 1973, Br. J. Pharmacol. 48: 369–386.Google Scholar
  144. 144.
    Kelly, J. S., and Renaud, L. P., 1973, Br. J. Pharmacol. 48: 387–395.PubMedCrossRefGoogle Scholar
  145. 145.
    Altmann, H., Bruggencate, G. Ten, Pickelman, P., and Steinberg, R., 1976, Brain Res. 111: 337–345.PubMedCrossRefGoogle Scholar
  146. 146.
    Altmann, H., Bruggencate, G. Ten, and Sonnhof, U., 1972, Pfluegers Arch. 331: 90–94.CrossRefGoogle Scholar
  147. 147.
    Tebecis, A. K., 1973, Exp. Neurol 40: 297–308.PubMedCrossRefGoogle Scholar
  148. 148.
    Champagnat, J., Denavit-Saubie, M., Moyanova, S., Rondouin, G., and Boudinot, E., 1981, Adv. Biochem. Psychopharmacol. 29: 89–95.PubMedGoogle Scholar
  149. 149.
    Bruggencate, G. Ten, and Enberg, I., 1971, Brain Res. 25: 431–448.PubMedCrossRefGoogle Scholar
  150. 150.
    Feldberg, W., and Rocha E. Silva, Jr., M„ 1981, Br. J. Pharmacol. 72: 17–24.PubMedCrossRefGoogle Scholar
  151. 151.
    Dray, A., Gonye, T. J., and Oakley, N. R., 1976, J. Physiol. (Lond.) 259: 825–849.Google Scholar
  152. 152.
    Cheramy, A., Nieoullon, A., and Glowinski, J., 1978, Eur. J. Pharmacol. 47: 141–147.PubMedCrossRefGoogle Scholar
  153. 153.
    Leviel, V., Cheramy, A., Nieoullon, A., and Glowinski, J., 1979, Brain Res. 175: 259–270.PubMedCrossRefGoogle Scholar
  154. 154.
    Finnerty, E. P., and Chan, S. H. H., 1980, Eur. J. Pharmacol. 67: 477–479.PubMedCrossRefGoogle Scholar
  155. 155.
    Kerwin, R. W., and Pycock, C. J., 1980, Eur. J. Pharmacol. 64: 169–172.PubMedCrossRefGoogle Scholar
  156. 156.
    Kerwin, R. W., and Pycock, C. J., 1979, Eur. J. Pharmacol. 54: 93–98.PubMedCrossRefGoogle Scholar
  157. 157.
    Young, A. B., and Snyder, S. H., 1973, Proc. Natl. Acad. Sci. U.S.A. 70: 2832–2836.PubMedCrossRefGoogle Scholar
  158. 158.
    Obata, K., and Yoshida, M., 1973, Brain Res. 64: 455–459.PubMedCrossRefGoogle Scholar
  159. 159.
    Gmndlach, A. L., and Beart, P. M., 1982, J. Neurochem. 38: 574–581.CrossRefGoogle Scholar
  160. 160.
    Curtis, D. R., Duggan, A. W., Felix, D., Johnston, G. A. R., and McLennan, H., 1971, Brain Res. 33: 57–73.PubMedCrossRefGoogle Scholar
  161. 161.
    Dreifuss, J. J., and Matthews, E. K., 1972, Brain Res. 45: 599–603.PubMedCrossRefGoogle Scholar
  162. 162.
    Felix, D., and McLennan, H., 1971, Brain Res. 25: 661–664.PubMedCrossRefGoogle Scholar
  163. 163.
    Kawamura, H., and Provini, L., 1970, Brain Res. 24: 293–304.PubMedCrossRefGoogle Scholar
  164. 164.
    Okamoto, K., and Sakai, Y., 1980, Br. J. Pharmacol. 69: 407–413.PubMedCrossRefGoogle Scholar
  165. 165.
    Kelly, J. S., and Krnjevié, K., 1969, Exp. Brain Res. 9: 155–163.PubMedCrossRefGoogle Scholar
  166. 166.
    Marciani, M. G., Stanzione, P., Cherubini, E., and Benardi, G., 1980, Neurosci. Lett. 18: 169–172.PubMedCrossRefGoogle Scholar
  167. 167.
    Blume, H. W., Pittman, Q. J., and Renaud, L. P., 1981, Brain Res. 209: 145–158.PubMedCrossRefGoogle Scholar
  168. 168.
    Ames, A., and Pollen, D. A., 1969, J. Neurophysiol. 32: 424–442.PubMedGoogle Scholar
  169. 169.
    Wyatt, H. J., and Daw, N. N., 1976, Science 191: 204–205.PubMedCrossRefGoogle Scholar
  170. 170.
    Miller, R. F., Frumkes, T. E., Slaughter, M., and Dacheux, R. F., 1981, J. Neurophysiol. 45: 764–782.PubMedGoogle Scholar
  171. 171.
    Frumkes, T. E., Miller, R. F., Slaughter, M., and Dacheux, R. F., 1981, J. Neurophysiol. 45: 783–804.PubMedGoogle Scholar
  172. 172.
    Cunningham, R., and Miller, R. F., 1980, Brain Res. 197: 123–138.PubMedCrossRefGoogle Scholar
  173. 173.
    Werman, R., 1979, Adv. Exp. Med. Biol. 123: 287–301.PubMedGoogle Scholar
  174. 174.
    Matthews, G., and Wickelgren, W. O., 1979. J. Physiol. (Lond.) 293: 393–415.Google Scholar
  175. 175.
    Homma, S., and Rooainen, C. M., 1978, J. Physiol. (Lond.) 279: 231–252.Google Scholar
  176. 176.
    Barker, J. L., Nicoli, R. A., and Padjen, A., 1975, J. Physiol. (Lond.) 245: 521–536.Google Scholar
  177. 177.
    Sonnhòf, U., Grafe, P., Krumnakl, J., Linder, M., and Schindler, L., 1975, Brain Res. 100: 327–341.PubMedCrossRefGoogle Scholar
  178. 178.
    Nistri, A., 1981, Adv. Biochem. Psychopharmacol. 29: 263–269.PubMedGoogle Scholar
  179. 179.
    Goldinger, A., and Muller, W. E., 1980, Neurosci. Lett. 16: 91–95.PubMedCrossRefGoogle Scholar
  180. 180.
    Barker, J. L., and McBurney, R. N., 1979, Nature 277: 234–236.PubMedCrossRefGoogle Scholar
  181. 181.
    Hòsli, L., Hòsli, E., Andres, P. F., and Landolt, H., 1981, Exp. Brain Res. 42: 43–48.PubMedGoogle Scholar
  182. 182.
    Zieglgansberger, W., and Champagnat, J., 1979, Brain Res. 160: 95–104.PubMedCrossRefGoogle Scholar
  183. 183.
    Rostad, J., 1981, Brain Res. 223: 397–401.CrossRefGoogle Scholar
  184. 184.
    Barker, J. L., and Ransom, B. R., 1978, J. Physiol. (Lond.) 280: 331–354.Google Scholar
  185. 185.
    Roberts, P. J., 1974, Brain Res. 67: 419–428.PubMedCrossRefGoogle Scholar
  186. 186.
    Cutler, R. W. P., 1976, Adv. Exp. Biol. Med. 69: 435–446.CrossRefGoogle Scholar
  187. 187.
    Fagg, G. E., Jordan, C. C., and Webster, R. A., 1978, Brain Res. 158: 159–170.PubMedCrossRefGoogle Scholar
  188. 188.
    Coull, B. M., and Cutler, R. W. P., 1978, Invest. Ophthalmol. 17: 682–684.Google Scholar
  189. 189.
    Coull, B. M., Owens, D. K., and Cutler, R. W. P., 1981, Brain Res. 210: 301–309.PubMedCrossRefGoogle Scholar
  190. 190.
    Reubi, J.-C., and Cuenod, M., 1976, Brain Res. 112: 347–361.PubMedCrossRefGoogle Scholar
  191. 191.
    Wolfensberger, M., Reubi, J. C., Canzek, V., Redweik, U., Curtius, H., and Cuenod, M., 1981, Brain Res. 224: 327–336.PubMedCrossRefGoogle Scholar
  192. 192.
    Barth, R., and Felix, D., 1974, Brain Res. 80: 532–537.PubMedCrossRefGoogle Scholar
  193. 193.
    Henke, H., and Cuenod, M., 1978, Brain Res. 152: 105–119.PubMedCrossRefGoogle Scholar
  194. 194.
    LeFort, D., Henke, H., and Cuenod, M., 1978, J. Neurochem. 30: 1287–1291.PubMedCrossRefGoogle Scholar
  195. 195.
    Streit, P., Knecht, E., and Cuenod, M., 1980, Brain Res. 187: 59–67.PubMedCrossRefGoogle Scholar
  196. 196.
    Clark, R. M., and Collins, G. G. S., 1976, J. Physiol. (Lond.) 262: 383–400.Google Scholar
  197. 197.
    Jasper, H. H., and Koyama, I., 1969, Can. J. Physiol. Pharmacol. 47: 889–905.PubMedCrossRefGoogle Scholar
  198. 198.
    Obata, K., and Takeda, K., 1969, J. Neurochem. 16: 1043–1047.PubMedCrossRefGoogle Scholar
  199. 199.
    Roberts, P. J., and Mitchell, J. F., 1972, J. Neurochem. 19: 2473–2481.PubMedCrossRefGoogle Scholar
  200. 200.
    Jordan, C. C., and Webster, R. A., 1971, Br. J. Pharmacol. 43: 441p–442 p.PubMedGoogle Scholar
  201. 201.
    Neal, M. J., 1971, J. Neurophysiol. 215: 103–117.Google Scholar
  202. 202.
    Hopkin, J., and Neal, M. J., 1971, Br. J. Pharmacol 42: 215–223.PubMedCrossRefGoogle Scholar
  203. 203.
    Cutler, R. W. P., Murray J. E., and Hammerstad, J. P., 1972, J. Neurochem. 19: 539–542.PubMedCrossRefGoogle Scholar
  204. 204.
    Mulder, A. H., and Snyder, S. H., 1974, Brain Res. 76: 297–308.PubMedCrossRefGoogle Scholar
  205. 205.
    Davidoff, R. A., and Adair, R., 1976, Brain Res. 118: 403–415.PubMedCrossRefGoogle Scholar
  206. 206.
    Vargas, O., deLorenzo, M., and Oriego, F., 1977, Neuroscience 2: 383–390.PubMedCrossRefGoogle Scholar
  207. 207.
    Bondy, S. C., Burks, J. S., and Harrington, M. E., 1979, Arch. Neurol. 36: 540–543.PubMedCrossRefGoogle Scholar
  208. 208.
    Mitchell, J. F., Neal, M. J., and Srinivasan, V., 1969, Br. J. Pharmacol. 36: 201P–202P.Google Scholar
  209. 209.
    Lopez-Colome, A. M., Tapia, R., Salcedaj, R., and Pasantes-Morales, H., 1978, Neuroscience 3: 1069–1074.PubMedCrossRefGoogle Scholar
  210. 210.
    Okamoro, K., and Namina, M., 1978, J. Neurochem. 31: 1393–1402.CrossRefGoogle Scholar
  211. 211.
    Roberts, P. J., 1974, Brain Res. 74: 327–332.PubMedCrossRefGoogle Scholar
  212. 212.
    Beart, P. M., and Bilal, K. B., 1976, Neurosci. Abstr. 2: 594.Google Scholar
  213. 213.
    Toggenburger, G., and Henke, H., 1981, Neurosci. Lett. [Suppl.] 7: 567.Google Scholar
  214. 214.
    Foster, A. C., and Roberts, P. J., 1980, J. Neurochem. 35: 517–519.PubMedCrossRefGoogle Scholar
  215. 215.
    Waller, M. B., and Richter, J. A., 1980, Biochem Pharmacol. 29: 2189–2198.PubMedCrossRefGoogle Scholar
  216. 216.
    Wenthold, R. J., 1979, Brain Res. 162: 338–343.PubMedCrossRefGoogle Scholar
  217. 217.
    Ehinger, B., and Lindberg-Bauer, B., 1976, Brain Res. 113: 535–549.PubMedCrossRefGoogle Scholar
  218. 218.
    Kennedy, A. J., and Neal, M. J., 1978, Exp. Eye Res. 26: 71–75.PubMedCrossRefGoogle Scholar
  219. 220.
    Levi, G,, Bernardi, G., Cherubini, E., Gallo, V., Mareiani, M. G., and Stanzione, P., 1982, Brain Res. 236: 121–131.PubMedCrossRefGoogle Scholar
  220. 221.
    McGale, E. H. F., Pye, I. F., Stonier, C., Hutchinson, E. C., and Aber, G. M. 1977, J. Neurochem. 29: 291–297.PubMedCrossRefGoogle Scholar
  221. 222.
    Franklin, G. M., Dudzinski, D. S., and Cutler, R. W. P., 1975, J. Neurochem. 24: 367–372.PubMedCrossRefGoogle Scholar
  222. 223.
    Dudzinski, D. S., and Cutler, R. W. P., 1974, J. Neurochem. 22: 355–361.PubMedCrossRefGoogle Scholar
  223. 224.
    Murray, J. E., and Cutler, R. W. P., 1970, J. Neurochem. 17: 703–704.PubMedCrossRefGoogle Scholar
  224. 225.
    Wright, E. M., 1974, Brain Res. 74: 354–358.CrossRefGoogle Scholar
  225. 226.
    Johnston, G. A. R., and Iversen, L. L., 1971, J. Neurochem. 18: 1951–1961.PubMedCrossRefGoogle Scholar
  226. 227.
    Logan, W. J., and Snyder, S. H., 1972, Brain Res. 42: 413–431.PubMedCrossRefGoogle Scholar
  227. 228.
    Bennett, J. P., Logan, W. J., and Snyder, S. H., 1972, Science 178: 997–999.PubMedCrossRefGoogle Scholar
  228. 229.
    Iversen, L. L., and Johnston, G. A. R., 1971, J. Neurochem. 18: 1939–1950.PubMedCrossRefGoogle Scholar
  229. 230.
    Arregui, A., Logan, W. J., Bennett, J. P., and Snyder, S. H., 1972, Proc. Natl. Acad. Sci. U.S.A. 69: 3485–3489.PubMedCrossRefGoogle Scholar
  230. 231.
    Levi, G., and Raiteri, M., 1974, Nature 250: 735–737.PubMedCrossRefGoogle Scholar
  231. 232.
    Iversen, L. L., 1975, Nature 253: 481.CrossRefGoogle Scholar
  232. 233.
    Aprison, M. H., and McBride, W. J., 1973, Life Sci. 12: 449–458.CrossRefGoogle Scholar
  233. 234.
    Henn, F. A., 1975, Metabolic Compartmentation and Neurotransmission (S. Berl, D. D. Clarke, and D. Schneider, eds.), Plenum Press, New York, pp. 91–97.CrossRefGoogle Scholar
  234. 235.
    Hannuniemi, R., and Oja, S. S., 1981, Neurochem. Res. 6: 873–884.PubMedCrossRefGoogle Scholar
  235. 236.
    Peterson, N. A., and Raghupathy, E., 1973, J. Neurochem. 21: 97–110.PubMedCrossRefGoogle Scholar
  236. 237.
    Muller, W. E., and Snyder, S. H., 1978, Brain Res. 143: 487–498.PubMedCrossRefGoogle Scholar
  237. 238.
    Wilkin, G. P., Csillag, A. Balazs, R., Kingsbury, A. E., Wilson, J. E., and Johnson, A. L., 1981, Brain Res. 216: 11–33.PubMedCrossRefGoogle Scholar
  238. 239.
    McGeer, E. G., and Singh, E. A., 1980, Neurosci. Lett. 17: 85–87.PubMedCrossRefGoogle Scholar
  239. 240.
    Bruun, A., and Ehinger, B., 1972, Invest. Ophthalmol. 11: 191–198.PubMedGoogle Scholar
  240. 241.
    Neal, M. J., 1976, Gen. Pharmacol. 7: 321–332.PubMedCrossRefGoogle Scholar
  241. 242.
    Lund Karlsen, R., 1978, J. Neurochem. 31: 1055–1061.CrossRefGoogle Scholar
  242. 243.
    Matus, A. I., and Dennison, M. E., 1972, J. Neurocytol. 1: 27–34.PubMedCrossRefGoogle Scholar
  243. 244.
    Ljungdahl, A., and Hokfelt, T., 1973, Brain Res. 62: 587–595.PubMedCrossRefGoogle Scholar
  244. 245.
    Dennison, M. E., Jordan, C. C., and Webster, R. A., 1976, J. Physiol. (Lond.) 258: 55P–56 P.Google Scholar
  245. 246.
    Price, D. P., Stocks, A., Griffin, J. W., Young, A., and Peck, K., 1976J. Cell Biol. 68: 389–395.PubMedCrossRefGoogle Scholar
  246. 247.
    Uchizono, K., 1965, Nature 207: 642–643.PubMedCrossRefGoogle Scholar
  247. 248.
    Riberio-da-Silva, A., and Coimbra, A., 1980, Brain Res. 188: 449–464.CrossRefGoogle Scholar
  248. 249.
    Hosli, L., and Hosli, E., 1978, Rev. Physiol. Biochem. Pharmacol. 81: 135–188.PubMedCrossRefGoogle Scholar
  249. 250.
    Hokfelt, T., and Ljungdahl, A., 1972, Adv. Biochem. Psychopharmacol. 6: 1–36.PubMedGoogle Scholar
  250. 251.
    Schwartz, I. R., 1981, Exp. Neurol. 73: 601–617.PubMedCrossRefGoogle Scholar
  251. 252.
    Voaden, M. J., Marshall, J., and Murani, M,, 1974, Brain Res. 67: 116–132.CrossRefGoogle Scholar
  252. 253.
    Pourcho, R. G., 1980, Brain Res. 198: 333–346.CrossRefGoogle Scholar
  253. 254.
    Marc, R. E., and Lam, D. M. K., 1981, J. Neurosci. 1: 152–165.PubMedGoogle Scholar
  254. 255.
    Larson, M. D., 1969, Brain Res. 15: 185–200.PubMedCrossRefGoogle Scholar
  255. 256.
    Curtis, D. R., Duggan, A. W., and Johnston, G. A. R., 1971, Exp. Brain Res. 12: 547–565.PubMedCrossRefGoogle Scholar
  256. 257.
    Evans, R. H., 1978, Br. J. Pharmacol. 62: 431P–432 P.PubMedCrossRefGoogle Scholar
  257. 258.
    Obata, K., Oide, M., and Tanaka, H., 1978, Brain Res. 144: 179–184.PubMedCrossRefGoogle Scholar
  258. 259.
    Felpel, L. P., 1972, Exp. Brain Res. 14: 494–502.PubMedCrossRefGoogle Scholar
  259. 260.
    Belcher, G., Ryall, R. W., and Schaffner, R., 1978, Brain Res. 151: 307–321.PubMedCrossRefGoogle Scholar
  260. 261.
    Bagust, J., Green, K. A., and Kerkut, G. A., 1981, Brain Res. 217: 425–429.PubMedCrossRefGoogle Scholar
  261. 262.
    Duggan, A. W., Griersmith, B. T., and Johnson, S. M., 1981, Brain Res. 210: 231–241.PubMedCrossRefGoogle Scholar
  262. 263.
    Ryall, R. W., Piercey, M. F., and Polosa, C., 1972, Brain Res. 41: 119–129.PubMedCrossRefGoogle Scholar
  263. 264.
    Belcher, G., Davis, J., and Ryall, R. W., 1976, J. Physiol. (.Lond.) 256: 651–662.Google Scholar
  264. 265.
    Curtis, D. R., Game, C. J. A., Lodge, D., and MeCulloch, R. M., 1976, J. Physiol. (Lond.) 258: 227–242.Google Scholar
  265. 266.
    Cullheim, S., and Kellerth, J.-O., 1981, J. Physiol. (Lond.) 312: 209–224.Google Scholar
  266. 267.
    Werman, R., 1966, Comp. Biochem. Physiol. 18: 745–766.PubMedCrossRefGoogle Scholar
  267. 268.
    Werman, R., 1972, Annu. Rev. Physiol. 34: 337–374.PubMedCrossRefGoogle Scholar
  268. 269.
    Straughn, D. W., 1974, Neuropharmacology 13: 495–508.CrossRefGoogle Scholar
  269. 270.
    Hill, R. G., Simmons, M. A., and Straughn, D. W., 1976, Br. J. Pharmacol. 56: 9–19.PubMedCrossRefGoogle Scholar
  270. 271.
    Precht, W., Schwindt, P. C., and Baker, R., 1973, Brain Res. 62: 222–226.PubMedCrossRefGoogle Scholar
  271. 272.
    Caspary, D. M., Havey, D. C., and Faingold, C. L., 1979, Brain Res. 172: 179–185.PubMedCrossRefGoogle Scholar
  272. 273.
    Yokota, T., Nishikawa, N., and Nishikawa, Y., 1979, Brain Res. 168: 430–434.PubMedCrossRefGoogle Scholar
  273. 274.
    Kitano, K., 1976, Neuropharmacology 15: 777–783.PubMedCrossRefGoogle Scholar
  274. 275.
    Ishida, Y., 1977, Neuropharmacology 16: 163–170.PubMedCrossRefGoogle Scholar
  275. 276.
    Mellanby, J., and Green, J., 1981, Neuroscience 6: 281–300.PubMedCrossRefGoogle Scholar
  276. 277.
    Curtis, D. R., and DeGroat, W. C., 1968, Brain Res. 10: 208–212.PubMedCrossRefGoogle Scholar
  277. 278.
    Curtis, D. R., Felix, D., Game, C. J. A., and McCulloch, R. M., 1973, Brain Res. 51: 358–362.PubMedCrossRefGoogle Scholar
  278. 279.
    Kryzhanovsky, G. N., 1973, Naunyn Schmiedebergs Arch. Pharmacol. 276: 247–270.PubMedCrossRefGoogle Scholar
  279. 280.
    Semba, T., and Kano, M., 1969, Science 64: 571–572.CrossRefGoogle Scholar
  280. 281.
    Johnston, G. A. R., DeGroat, W. C., and Curtis, D. R., 1969, J. Neurochem. 16: 797–800.PubMedCrossRefGoogle Scholar
  281. 282.
    Fedine, A. A., and Shank, R. P., 1971, J. Neurochem. 18: 2229–2234.CrossRefGoogle Scholar
  282. 283.
    Hilbig, G., Raker, K. O., and Wellhohoner, H. H., 1979, Naunyn Schmiedebergs Arch. Pharmacol. 307: 287–290.PubMedCrossRefGoogle Scholar
  283. 284.
    Schwab, M. E., and Thoenen, H., 1976, Brain Res. 105: 213–227.PubMedCrossRefGoogle Scholar
  284. 285.
    Price, D. L., Griffin, J. W., and Peck, K., 1977, Brain Res. 121: 379–384.PubMedCrossRefGoogle Scholar
  285. 286.
    Price, D. L., and Griffin, J. W., 1981, Neurosci. Lett. 23: 149–155.PubMedCrossRefGoogle Scholar
  286. 287.
    Zukin, S. R., Young, A. B., and Snyder, S. H., 1975, Brain Res. 83: 525–530.PubMedCrossRefGoogle Scholar
  287. 288.
    Snyder, S. H., 1975, Br. J. Pharmacol. 53: 473–484.PubMedCrossRefGoogle Scholar
  288. 289.
    Zarbin, M. A., Wamsley, J. K., and Kuhar, M. J., 1981, J. Neurosci. 1: 532–547.PubMedGoogle Scholar
  289. 290.
    Palacios, J. M., Wamsley, J. K., Zarbin, M. A., and Kuhar, M. J., 1981, Adv. Biochem: Psychopharmacol. 29: 445–451.Google Scholar
  290. 291.
    Hosli, E., and Hosli, L., 1981, Brain Res. 213: 242–245.PubMedCrossRefGoogle Scholar
  291. 292.
    Schaffer, J. M. and Anderson, S. M., 1981, J. Neurochem. 36: 1597–1600.CrossRefGoogle Scholar
  292. 293.
    Borbe, H. O., Miiller, W. E., and Wohlert, U., 1981, Brain Res. 205: 131–139.PubMedCrossRefGoogle Scholar
  293. 294.
    Graham, D., Pfeiffer, F., and Betz, H., 1981, Biochem. Biophys. Res. Commun. 102: 1330–1335.PubMedCrossRefGoogle Scholar
  294. 295.
    Pfeifer, F., and Betz, H., 1981, Brain Res. 226: 273–279.CrossRefGoogle Scholar
  295. 296.
    Mackerer, C. R., Kochman, R. L., Shen, T. F., and Hershenson, F. M., 1977, J. Pharmacol. Exp. Ther. 201: 326–331.PubMedGoogle Scholar
  296. 297.
    Hershenson, F. M., Prodan, K. A., Kochman, R. L., Bloss, J. L., and Mackerer, C. R., 1977, J. Med. Chem. 20: 11–14.CrossRefGoogle Scholar
  297. 298.
    Hayashi, H., Suga, M., Satake, M., and Tsubaki, T., 1981, Ann. Neurol. 9: 292–294.PubMedCrossRefGoogle Scholar
  298. 299.
    Curtis, D. R., Lodge, D., Johnston, G. A. R., and Brand, S. J., 1976, Brain Res. 118: 344–347.PubMedCrossRefGoogle Scholar
  299. 300.
    Dray, A,, and Straughn, D, W., 1976, J. Pharm, Pharmacol. 28: 314–315.CrossRefGoogle Scholar
  300. 301.
    Costa, E., Guidotti, A., Mao, C. C., and Suria, A., 1975, Life Sci. 17: 167–186.PubMedCrossRefGoogle Scholar
  301. 302.
    Squires, R. F., and Braestrup, C., 1977, Nature 266: 732–734.PubMedCrossRefGoogle Scholar
  302. 303.
    Hunt, P., and Raynaud, J.-P., 1977, J. Pharm. Pharmacol. 29: 442–444.PubMedCrossRefGoogle Scholar
  303. 304.
    Kishimoto, H., Simon, J. R., and Aprison, M. H., 1981, Neurochem. 37: 1015–1024.CrossRefGoogle Scholar
  304. 305.
    Perry, T. L., Urquhart, N., MacLean, J., Evans, M. E., Hansen, S., Davidson, A. G. F., Applegarth, D. A., MacLeod, P. J., and Lock, J. E., 1975, N. Engl J. Med. 292: 1269–1272.PubMedCrossRefGoogle Scholar
  305. 306.
    Perry, T. L., Urquhart, N., Hansen, S., and Mamer, O. A., 1977, Pediatr. Res. 11: 1192–1197.PubMedCrossRefGoogle Scholar
  306. 307.
    Dalla Bernardina, B., Aicardi, J., Goutiéres, F., andPlouin, P., 1979, Neuropaediatrie 10: 209–225.CrossRefGoogle Scholar
  307. 308.
    Frazier, D. M., Summer, G. K., and Chamberlain, H. R., 1978, Am. J. Dis. Child. 132: 777–781.PubMedGoogle Scholar
  308. 309.
    Holmgren, G., and Blomquist, H. K., 1977, Neuropaediatrie 8: 67–72.CrossRefGoogle Scholar
  309. 310.
    Rosenberg, L. E., 1978, The Metabolic Basis of Inherited Disease, 4th ed. ( J. B. Stanbury, J. B. Wyngaarden, and D. S. Frederickson, eds.), McGraw-Hill, New York, pp. 411–429.Google Scholar
  310. 311.
    Harris, D. J., Thompson, R. M., Wolf, B., and Yang, B. I.-Y., 1981, J. Med. Genet. 18: 156–157.PubMedCrossRefGoogle Scholar
  311. 312.
    Bank, W. J., Pizer, L., and Pfender, W., 1978, Adv. Neurol. 21: 267–278.PubMedGoogle Scholar
  312. 313.
    Brandt, N. J., Rasmussen, K., Brandt, S., Kolvraa, S., and Shonheyder, F., 1976, Acta Paediatr. Scand. 65: 17–22.PubMedCrossRefGoogle Scholar
  313. 314.
    O’Brien, W. E., 1978, Arch. Biochem. Biophys. 189: 291–297.PubMedCrossRefGoogle Scholar
  314. 315.
    Kolvraa, S., 1979, Pediatr. Res. 13: 889–893.PubMedCrossRefGoogle Scholar
  315. 316.
    Ugarte, M., Lopez-Lahoya, J., Garcia, M. L., Benavides, J., and Valdivieso, F., 1979, J. Inherit. Metab. Dis. 2: 93–96.CrossRefGoogle Scholar
  316. 317.
    Lopez-Lahoya, J., Garcia, M. L., Benavides, J., and Ugarte, M., 1981, J. Neurochem. 36: 325–327.PubMedCrossRefGoogle Scholar
  317. 318.
    Ando, T., Nyhan, W. L., Gerritsen, T., Gong, L., Heiner, D. C., and Bray, P. F., 1968, Pediatr. Res. 2: 254–263.PubMedCrossRefGoogle Scholar
  318. 319.
    Hiraga, K., Kochi, H., Hayasaka, K., Kikuchi, G., and Nyhan, W., 1981, J. Clin. Invest. 68: 525–534.PubMedCrossRefGoogle Scholar
  319. 320.
    Wendt, L. von, Similá, S., Saukkonen, A.-L., Koivisto, M., and Kouvalainen, K., 1981, Am. J. Dis. Child. 135: 1072.Google Scholar
  320. 321.
    Garcia-Castro, J. M., Isales-Forsythe, C. M., Levy, H. L., Shih, V. E., Lao Velez, C. R., Gonzalez-Rios, M. D. C., and DeTorres, L. C. R., 1982, N. Engl. J. Med. 306: 79–81.PubMedCrossRefGoogle Scholar
  321. 322.
    Wendt, L. V., Alanko, H., Sorri, M., Toivakka, E., Saukkonen, A.-L., and Similá, S., 1981, Clin. Genet. 19: 94–100.CrossRefGoogle Scholar
  322. 323.
    DeGroot, C. J., Boelieverts, V., Touwen, B. C. L., and Hommes, F. A., 1978, Prog. Brain Res. 48: 199–205.CrossRefGoogle Scholar
  323. 324.
    Ransom, B. R., and Nelson, P. G., 1976, N. Engl. J. Med. 294: 1295–1296.PubMedGoogle Scholar
  324. 325.
    Benavides, J., Lopez-Lahoya, J., Valdivieso, F., and Ugarte, M., 1981, J. Neurochem. 37: 315–320.PubMedCrossRefGoogle Scholar
  325. 326.
    Wellner, D., and Meister, A., 1981, Annu. Rev. Biochem. 50: 911–968.PubMedCrossRefGoogle Scholar
  326. 327.
    Lane, J. D., Schone, B., Langenbeck, U., and Neuhoff, V., 1980, Biochim. Biophys. Acta 627: 144–156.PubMedCrossRefGoogle Scholar
  327. 328.
    Isaacs, C. E., and Greengard, O., 1980, Biochem. J. 192: 441–448.PubMedGoogle Scholar
  328. 329.
    Dienel, G. A., 1981, J. Neurochem. 36: 34–43.PubMedCrossRefGoogle Scholar
  329. 330.
    Valdivieso, F., Ugarte, M., Maties, M., Gimenez, C., and Mayor, F., 1977, J. Ment. Defic. Res. 21: 95–102.PubMedGoogle Scholar
  330. 331.
    Snyderman, S. E., Sansaricq, C., Norton, P. M., and Castro, J. V., 1981, J. Pediatr. 99: 63–67.Google Scholar
  331. 332.
    Hall, P. V., Smith, J. E., Campbell, R. L., Felten, D. L., and Aprison, M. H., 1976, Life Sci. 18: 1467–1472.PubMedCrossRefGoogle Scholar
  332. 333.
    Rizzoli, A. A., 1968, Brain Res. 11: 11–18.PubMedCrossRefGoogle Scholar
  333. 334.
    Smith, J. E., Hall, P. V., Galvin, M. R., Jones, A. R., and Campbell, R. L., 1979, Neurosurgery 4: 152–156.PubMedCrossRefGoogle Scholar
  334. 335.
    Stern, P., and Hadzovic, J., 1970, Life Sci. 9: 955–959.CrossRefGoogle Scholar
  335. 336.
    Barbeau, A., 1974, Neurology (Minneap.) 24: 392.Google Scholar
  336. 337.
    Stern, P., and Bokonjic, R., 1974, Pharmacology 12: 117–119.PubMedCrossRefGoogle Scholar
  337. 338.
    Potashner, S. J., 1979, J. Neurochem. 32: 103–109.PubMedCrossRefGoogle Scholar
  338. 339.
    vanGelder, N. M., Sherwin, A. L., and Rasmussen, T., 1972, Brain Res. 40: 385–393.CrossRefGoogle Scholar
  339. 340.
    Perry, T. L., and Hansen, S., 1981, Neurology (Minneap.) 31: 872–876.CrossRefGoogle Scholar
  340. 341.
    vanGelder, N. M., and Courtois, A., 1972, Brain Res. 43: 477–484.CrossRefGoogle Scholar
  341. 342.
    Lapin, I. P., 1981, Eur. J. Pharmacol. 71: 495–498.PubMedCrossRefGoogle Scholar
  342. 343.
    Cherubim, E., Beraardi, G., Stanzione, P., Marciani, M. G., andMereuri, N., 1981, Neurosci. Lett. 21: 93–97.CrossRefGoogle Scholar
  343. 344.
    Fariello, R. G., 1979, Exp. Neurol 66: 55–63.PubMedCrossRefGoogle Scholar
  344. 345.
    Simila, S., Wendt, L. von, and Linna, S. L., 1980, J. Neurol. Sci. 45: 83–86.PubMedCrossRefGoogle Scholar
  345. 346.
    Mortensen, P. B., Kolvraa, S., and Christensen, E., 1980, Epilepsia 21: 563–569.PubMedCrossRefGoogle Scholar
  346. 347.
    Hayasaka, K., Kochi, H., Hiraga, K., and Kikuchi, G., 1981, Biochem. Int. 1: 410–416.Google Scholar
  347. 348.
    Schecter, P. J., Tranier, Y., and Grove, J., 1978, J. Neurochem. 31: 1325–1327.CrossRefGoogle Scholar
  348. 349.
    Carl, G. F., Crews, E. L., Carmichael, S. M., Benesh, F. C., and Smythies, J. R., 1978, Biol. Psychiatry 13: 773–776.PubMedGoogle Scholar
  349. 350.
    Pepplinkhuizen, L., Blom, W., Bruinvels, J., and Moleman, P., 1980, Lancet 1: 454–456.PubMedCrossRefGoogle Scholar
  350. 351.
    Rosenblatt, S., Gaull, G. E., Chanley, J. D., Rosenthal, J. S., Smith, H., and Sarkozi, L., 1979, Am. J. Psychiatry 136: 672–674.PubMedGoogle Scholar
  351. 352.
    Shea, P. A., Small, J. G., and Hendrie, H. C., 1981, Biol. Psychiatry 16: 825–830.PubMedGoogle Scholar
  352. 353.
    Deutsch, S. I., Peselow, E. D., Banay-Schwartz, M., Gershon, S., Virgilio, J., Fieve, R. R., and Rotrosen, J., 1981, Am. J. Psychiatry 138: 683–684.PubMedGoogle Scholar
  353. 354.
    Deutsch, S. I., Stanley, M., Banay-Schwartz, M., Peselow, E. D., Virgilio, J., Geisler, S., and Mohs, R. C., 1981, Eur. J. Pharmacol. 75: 75–76.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • E. C. Daly
    • 1
    • 2
    • 3
    • 4
  • M. H. Aprison
    • 1
    • 2
    • 3
    • 4
  1. 1.The Institute of Psychiatric ResearchIndiana University School of MedicineIndianapolisUSA
  2. 2.Department of PsychiatryIndiana University School of MedicineIndianapolisUSA
  3. 3.Department of NeurologyIndiana University School of MedicineIndianapolisUSA
  4. 4.Department BiochemistryIndiana University School of MedicineIndianapolisUSA

Personalised recommendations