Possibilities for Use of Endotoxin in Compromised Subjects

  • Richard I. Walker


The basic idea suggesting that pyrogenic agents may be beneficial to medicine is not new. Around 500 B.C., Parmenides, a Greek physician, stated, “If only I had the means of creating fever artificially, I should be able to cure all illnesses” (Westphal et al., 1977). Over 2000 years later, the pyrogenic principle was found to be endotoxin. Fever therapy using whole gram-negative microorganisms had been in use for about 50 years when Boivin et al. (1933) described a method to purify the endotoxic material.


Newcastle Disease Virus Pertussis Vaccine Bacterial Endotoxin Yersinia Pestis Endotoxin Shock 


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© Plenum Press, New York 1983

Authors and Affiliations

  • Richard I. Walker
    • 1
  1. 1.Naval Medical Research InstitutBethesdaUSA

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