Effect of LPS on Nonspecific Resistance to Bacterial Infections

  • Monique Parant


Bacterial endotoxins may affect the pathogenicity of a wide variety of infectious agents, not only gram-negative and gram-positive bacteria, but also fungi, parasites, and viruses. Originally demonstrated by Rowley (1956) using bacterial cell walls, and shortly later by several workers with partially purified endotoxins (Landy and Pillemer, 1956; Dubos and Schaedler, 1956), this capacity to nonspecifically enhance the host’s resistance to a bacterial infection created more excitement about these substances (reviewed in Cluff, 1971). Subsequently, during the 1960s, chemical and physical methods of modifying these complex toxins without destroying their protective properties were developed (reviewed in Sultzer, 1971). A significant but transient increase in resistance to infection has been observed when endotoxin is given several hours before initiation of infection, and very low doses of endotoxin were found to be effective (see Cluff, 1971). However, depending upon the dose and route of administration, and upon the time interval prior to the infectious challenge, a transient increase in susceptibility to infection was also reported in the first papers (Rowley, 1956; Landy and Pillemer, 1956; Dubos and Schaedler, 1956). This negative phase has been produced when endotoxin is injected at the time of challenge or shortly thereafter.


Bacterial Infection Bone Marrow Cell Mouse Strain Bacterial Endotoxin Phthalic Anhydride 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Monique Parant
    • 1
  1. 1.Immunothérapie ExpérimentaleInstitut PasteurParis Cedex 15France

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