Immunogenicity of Endotoxin

  • Erwin Neter


Endotoxin or lipopolysaccharide (LPS) is one of the most extraordinary bacterial products because of the variety of biologic effect it engenders in susceptible animals. Some of these reactions are undesirable, since they may be associated with pathologic changes and even with death. Others are beneficial when the result is enhanced resistance or immunity to toxemia and/or infection. It must be emphasized, however, that, depending upon the degree of reaction and the particular circumstances, one and the same effect may be either beneficial or harmful. Thus, high fever may have undesirable results or, as utilized some time ago, may be curative when used in patients to cure certain diseases or to enhance resistance. Pyrogenicity has been studied for more than two centuries, as reviewed in depth by Westphal et al. (1977). Similarly, an immune response to a given antigenic determinant may have either beneficial, harmful, or indifferent effects.


Antibody Response Oral Immunization Specific Antibody Response Typhoid Vaccine Common Enterobacterial Antigen 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Erwin Neter
    • 1
    • 2
  1. 1.Departments of Microbiology and PediatricsState University of New York at BuffaloBuffaloUSA
  2. 2.Laboratory of BacteriologyChildren’s HospitalBuffaloUSA

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