Induced Enhanced Resistance to Transplantable Tumors in Mice

  • Paul H. Saluk


The first systematic studies of bacterial vaccines in the treatment of human cancer were performed by W. B. Coley (1891, 1893, 1898, 1906). Additional reports of cancer treatment with such vaccines appeared although not all were of a positive nature (reviewed by Nauts et al., 1946). The use of Coley’s toxins (mixtures of Streptococcus pyogenes and Serratia marcescens) fell into disfavor because of a lack of consistency, which was due, in part, to a lack of potency and a lack of knowledge regarding dosage, site of administration, and frequency of injections. However, a case study by Nauts et al. (1953) revealed the effectiveness of Coley’s toxins when these parameters were taken into consideration. Interest in bacterial products was revived by the experiments of Shwartzman and Michailovsky (1932) and of Duran-Reynals (1935) wherein they showed that bacterial filtrates of gram-negative organisms were effective in producing hemorrhagic necrosis of murine tumors.


Serratia Marcescens Antitumor Response Peritoneal Cell Transplantable Tumor Ascites Tumor 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Paul H. Saluk
    • 1
  1. 1.Department of Microbiology and ImmunologyHahnemann Medical College and HospitalPhiladelphiaUSA

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