The Effect of Endotoxins on Skin and Kidney Transplantation Reactions

  • Ewa Skopińska-Różewska


Transplantation immunity involves the development of cellular-type immunity to the donor histocompatibility antigens, and the production of humoral antibodies stimulated by these antigens. It is reasonable to expect that in the near future the classical nonspecific immunosuppressive therapy used to prevent or to reduce immune reactions caused by transplantation will be replaced by more “specific” treatment that will not interfere with the immunological response of the host to other antigens besides those of the donof. Such treatment in the future will be based upon reinforcing the reactions leading to the production of protective factors and suppressing reactions that lead to the damage of the transplant. Before commencing such a regimen of immunosuppression (or, rather, immunomodulation), the influence of various incidental factors should be established. Among these, the bacterial endotoxins appear to have explicit importance.


Spleen Cell Migration Inhibition Factor Graft Survival Skin Graft Mixed Lymphocyte Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abdelnoor, A., Chang, C. M., and Nowotny, A., 1972, Effect of antilymphocyte serum on endotoxin reactions, Bacteriol. Proc. 1972:92.Google Scholar
  2. Adelman, N. E., Ksiazek, J., Yoshida, T., and Cohen, S., 1980, Lymphoid sources of murine migration inhibition factor,J. Immunol. 124:825.PubMedGoogle Scholar
  3. Adorini, L., Ruco, L., Uccini, S., Soravito De Franceschi, G., Baroni, C. D., and Doria, C., 1976, Biological effects of Escherichia coli lipopolysaccharide (LPS) in vivo. II. Selection in the mouse thymus of PHA- and Con A-responsive cells, Immunology 31:225.PubMedGoogle Scholar
  4. Al-Askari, S., Zweiman, B., Lawrence, H. S., and Thomas, L., 1964, The effect of endotoxin on skin homografts in rabbits,J. Immunol. 93:742.PubMedGoogle Scholar
  5. Allison, A. C., Davies, P., and Page, R. C., 1973, Effects of endotoxin on macrophages and other lymphoreticular cells,J. Infect. Dis. 128(Suppl.):212.PubMedCrossRefGoogle Scholar
  6. Armerding, D., and Katz, D. H., 1974, Activation of T and B lymphocytes in vitro. I. Regulatory influence of bacterial lipopolysaccharide (LPS) on specific T-cell helper function,J. Exp. Med. 139:24.PubMedCrossRefGoogle Scholar
  7. Baroni, C. D., Ruco, L., Soravito De Franceschi, G., Uccini, S., Adorini, L., and Doria, G., 1976, Biological effects of Escherichia col. lipopolysaccharide (LPS) in vivo. I. Selection in the mouse thymus of killer and helper cells, Immunology 31:217.PubMedGoogle Scholar
  8. Ghase, R. M., and Rapaport, F. I., 1965, The bacterial induction of homograft sensitivity. I. Effects of sensitization with group A streptococci,J. Exp. Med. 122:721.CrossRefGoogle Scholar
  9. Eidemiller, L. R., and Bell, P. R. F., 1972, Migration inhibition and homograft rejection in rats, Transplantation 13:5.PubMedCrossRefGoogle Scholar
  10. Elie, R., and Lapp, W. F., 1977, Graft versus host-induced immunosuppression: Mechanism of depressed T-cell helper function in vitro, Cell. Immunol. 34:38.PubMedCrossRefGoogle Scholar
  11. Elkins, W. L., 1966, The interaction of donor and host lymphoid cells in pathogenesis of renal cortical destruction induced by a local graft versus host reaction, J Exp. Med. 123:103.PubMedCrossRefGoogle Scholar
  12. Floersheim, G. L., 1969, Suppression of cellular immunity by gram-negative bacteria, Antibwt. Chemother. 15:407.Google Scholar
  13. Forbes, J. T., Nakao, Y., and Smith, R. T., 1975, T mitogens trigger LPS responsiveness in mouse thymus cells,J. Immunol. 114:1004.PubMedGoogle Scholar
  14. Fox, R. A., and Rajaraman, K., 1978, The role of suppressor cells in the production of macrophage migration inhibition factor, Immunol. Commun. 7:311.PubMedGoogle Scholar
  15. Haskovcova, H., and Nouza, K., 1970, Treatment and pretreatment of graft-versus-host reaction by antilymphocyte serum, Folia Biol. (Prague) 16:397.Google Scholar
  16. Hirata, A. A., Mclntire, F. G., Terasaki, P. I., and Mittal, K. K., 1973, Cross reactions between human transplantation antigens and bacterial lipopolysaccharides, Transplantation 15:441.PubMedCrossRefGoogle Scholar
  17. Husberg, B., Nilsson, T., and Fritz, H., 1971, Acute rejection of allogeneic transplanted kidneys following nephrectomy of autogeneic pyelonephritic kidneys, Transplantation 11:1971.CrossRefGoogle Scholar
  18. Kagnoff, M. F., Billings, P., and Gohn, M., 1974, Functional characteristics of Peyer’s patch lymphoid cells. II. LPS is thymus dependent,J. Exp. Med. 139:407.PubMedCrossRefGoogle Scholar
  19. Kirpatovski, I. D., and Stanislawski, E. S., 1971, Immunosuppressive effect of cell-free extracts from Escherichia coli, Transplant. Proc. 3:831.PubMedGoogle Scholar
  20. Klassen, J., and Milgrom, F., 1970, The generalized Shwartzman phenomenon in rabbits with dencrvated kidneys, Proc. Soc. Exp. Biol. Med. 134:980.PubMedGoogle Scholar
  21. Klassen, J., and Milgrom, F., 1971, Studies on cortical necrosis in rabbit renal homograft, Transplantation 11:35.PubMedCrossRefGoogle Scholar
  22. Marecki, N. M., and Bradley, S. G., 1973, Enhanced toxicity for mice of combinations of bacterial endotoxin with antitumor drugs, Antimicrob. Agents Chemother. 3:599.PubMedGoogle Scholar
  23. Mazzolli, A. B., and Barrera, G., 1974, A method for detecting cytophilic activity in a homologous system,J. Immunol. Methods 4:31.CrossRefGoogle Scholar
  24. Morris, P. J., Kincaid, S. P., and McKenzie, I. F. C., 1969, Leukocyte antigens in renal transplantation: Immediate renal allograft rejection with a negative cross-match, Med. J. Amt. 56:379.Google Scholar
  25. Nowotny, A., Radvany, R., and Neale, N. E., 1965, Neutralization of toxic bacterial O-an-tigens with O-antibodies while maintaining their stimulus on non-specific resistance, Life Sci. 4:1107.PubMedCrossRefGoogle Scholar
  26. Ostrowski, K., Skopinska, E., Sankowski, A., Pienkowski, M., and Priegnitz, A., 1968, Antigen-induced changes in regional lymph nodes of mice. I. Allogeneic cells, Bull. Acad. Polon. Sa. Sér. Biol. 16:217.Google Scholar
  27. Ostrowski, K., Skopinska, E., Lazarewicz, J., Gorski, A., Zaleska-Rutczynska, Z., and Sankowski, A., 1969, The range and sensitivity of migration inhibition test used for estimation of antigenicity of splenic microsomal fraction, Folia Biol. (Prague) 15:146.Google Scholar
  28. Persson, U., 1977, Lipopolysaccharide-induced suppression of the primary immune response to a thymus-dependent antigen,J. Immunol. 118:789.PubMedGoogle Scholar
  29. Pickel, K., and Hoffmann, M. K., 1977, Suppressor T cells arising in mice undergoing a graft-vs.-host response,J. Immunol. 118:653.PubMedGoogle Scholar
  30. Quesenberry, P., Morley, A., Stohlman, F., Jr., Rickard, K., Howard, D., and Smith, M., 1972, Effect of endotoxin on granulopoiesis and colony-stimulating factor, N. Engl. J. Med. 286:227.PubMedCrossRefGoogle Scholar
  31. Rowlands, D. T., Claman, H. N., and Kind, P. D., 1965, The effect of endotoxin on the thymus of young mice, Am. J. Pathol. 46:165.PubMedGoogle Scholar
  32. Sankowski, A., Skopinska, E., Lazarewicz, J., Gorski, A., and Ostrowski, K., 1969, Effect of azathioprine on allograft sensitivity: Study of spleen cell migration, Bull. Acad. Polon. Sér. Sci. Biol. 17:223.Google Scholar
  33. Skopinska, E., 1972, Some effects of Escherichia coll endotoxin on the graft-versus-host reaction in mice, Transplantation 14:432.PubMedCrossRefGoogle Scholar
  34. Skopinska, E., 1974a, The effect of E. coli endotoxin on the GVH reaction in mice. II. Non H-2 systems, Arch. Immunol. Ther. Exp. (Engl. Ed.) 22:301.Google Scholar
  35. Skopiiiska, E., 1974b, The effect of E. coli endotoxin on the GVH reaction in mice. III. Runt disease in newborns, Arch Immunol. Ther. Exp. (Engl. Ed.) 22:305.Google Scholar
  36. Skopinska, E., 1976, The effect of E. coli lipopolysaccharide (endotoxin) on the GVH reaction in mice. IV, Ann. Med. Sect. Pol. Acad. Sci. 21:185.PubMedGoogle Scholar
  37. Skopiiiska, E., 1978, Effect of lipopolysaccharide on the development of cell-mediated immunity to transplantation antigens, Transplantation 26:420.CrossRefGoogle Scholar
  38. Skopinska, E., and Lukasik, R., 1979, Production of lymphocyte migration inhibitory (LyMIF) and stimulatory (LyMSF) factors by T and B lymphocytes from rabbit peripheral blood stimulated with Con A, Bull. Acad. Polon. Sér. Sci. Biol. 27:701.Google Scholar
  39. Skopiiiska, E., and Nowaczyk, M., 1979, A one-stage test for simultaneous study of migration inhibition factor of peripheral leukocytes (LIF) and migration inhibition factor of mouse spleen cells (MSIF), Arch. Immunol. Ther. Exp. (Warsaw) 27:171.Google Scholar
  40. Skopinska, E., and Oluwasanmi, J. O., 1972, Effect of Escherichia coli endotoxin on skin allografts in mice, Folia Biol. (Prague) 18:270.Google Scholar
  41. Skopiiiska, E., Sankowski, A., and Nouza, K., 1969, Effect of azathioprine on the development of allograft sensitivity in mice, Bull. Acad. Polon. Sér. Sa. Biol. 17:85.Google Scholar
  42. Skopinska, E., Wasik, M., and Wojtulewicz-Kurkus, J., 1971, Indirect migration inhibition test in xenogeneic systems. III. Cellular immunity to kidney grafts, Arch. Immunol. Ther. Exp. (Engl. Ed.) 19:377.Google Scholar
  43. Skopinska, E., Nowaczyk, M., Gorski, A., Wasik, M., Krzywicka, E., Wojtulewicz-Kurkus, J., and Orlowski, T., 1974, The influence of antithymocytic serum, a-globulins, and E. coli endotoxin on the development of cellular immunity in experimental skin and kidney transplantation, Abstracts, International Conference of Allergologists and Clinical Immunologists of Socialist Countries, Prague, p. 43.Google Scholar
  44. Skopiiiska, E., Nowaczyk, M., Gorski, A., and Glyda, J., 1977, Studies on MIF production following transplantation of an allogeneic kidney in the rabbit, Immunol. Pol. 2:153.Google Scholar
  45. Skopiiiska, E., Ziembikiewicz, A., Lukasik, R., and Misztal, B., 1978a, The appearance of factors influencing migration of lymphocytes (LyMIF and LyMSF) in rabbit mixed lymphocyte cultures, Arch. Immunol. Ther. Exp. (Engl. Ed.) 26:389.Google Scholar
  46. Skopińska, E., Wasik, M., Moscicka-Wesolowska, M., Wojtulewicz-Kurkus, J., and Lukasik, R., 1978b, The effect of ATG treatment on LyMIF and LyMSF production in MLC of rabbits after renal allotransplantation, Arch. Immunol. Ther. Exp. (Engl. Ed.) 26:987.Google Scholar
  47. Skopiiiska, E., Madalinski, W., Lukasik, R., 1983, Some characteristics of human lymphocyte migration inhibitory factor and the effect of ampicillin on its appearance in PHA-stimulated cultures, Acta Physiol. Pol. (in press).Google Scholar
  48. Starzl, T. E., Lorner, R. A., Dixon, F. J., Groth, C. G., Brettschneider, L., and Terasaki, P. I., 1968, Shwartzman reaction after human renal homotransplantation, N. Engl. J. Med. 278:642.PubMedCrossRefGoogle Scholar
  49. Stetson, C. A., 1955, Studies on the mechanism of the Shwartzman phenomenon: Similarities between reactions to endotoxin and certain reactions of bacterial allergy, J. Exp. Med. 101:421.PubMedCrossRefGoogle Scholar
  50. Terino, E. O., Miller, J., and Glenn, W. W. L., 1964, Tolerance induction and skin graft prolongation by competing antigens, Surgery 56:256.PubMedGoogle Scholar
  51. Toledo-Pereyra, L. H., Raij, L., Simmons, R. L., and Najarian, J. S., 1974, Role of endotoxin and bacteria in long-term survival of preserved small-bowel allografts, Surgery 76:474.PubMedGoogle Scholar
  52. Veit, B. C., and Michael, J. G., 1972, The lack of thymic influence in regulating the immune response to E. coli O127 endotoxin,J. Immunol. 109:547.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Ewa Skopińska-Różewska
    • 1
  1. 1.Division of Experimental Immunosuppression, Transplantation InstituteWarsaw Medical SchoolWarsawPoland

Personalised recommendations