Effect of Endotoxin on Graft-versus-Host Reactions

  • P. Liacopoulos


The graft-versus-host (GVH) reaction, in the same way as other reactions of humoral or cellular immunity, is regulated by a set of cellular interactions produced either by direct cell-to-cell contact or through the mediation of soluble factors released by the activated cells. It would therefore not be surprising if the potent immunoregulatory properties of bacterial lipopolysaccharides (LPS) were also observed in the GVH reaction. This reaction is initiated by a “graft” of immunologically competent lymphocytes introduced into a “host” that confronts the graft with a major histocompatibility (MHC) difference, without being itself able to mount a similar immunological attack against the donor lymphoid cells. Indeed, if the host is immunologically competent, the host-versus-graft (HVG) reaction precedes by a few days the GVH reaction and eliminates or inactivates allogeneic cells.


Spleen Cell Donor Cell Cell Transfer Bacterial Endotoxin Donor Treatment 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • P. Liacopoulos
    • 1
  1. 1.Institut d’Immunobiologie (INSERM U.20, CNRS, L.A. 143)Hôpital BroussaisParis Cedex 14France

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