Advertisement

Effect of Endotoxin on Graft-versus-Host Reactions

  • P. Liacopoulos

Abstract

The graft-versus-host (GVH) reaction, in the same way as other reactions of humoral or cellular immunity, is regulated by a set of cellular interactions produced either by direct cell-to-cell contact or through the mediation of soluble factors released by the activated cells. It would therefore not be surprising if the potent immunoregulatory properties of bacterial lipopolysaccharides (LPS) were also observed in the GVH reaction. This reaction is initiated by a “graft” of immunologically competent lymphocytes introduced into a “host” that confronts the graft with a major histocompatibility (MHC) difference, without being itself able to mount a similar immunological attack against the donor lymphoid cells. Indeed, if the host is immunologically competent, the host-versus-graft (HVG) reaction precedes by a few days the GVH reaction and eliminates or inactivates allogeneic cells.

Keywords

Spleen Cell Donor Cell Cell Transfer Bacterial Endotoxin Donor Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Andersson, J., Sjöberg, O., and Möller, G., 1972, Mitogens as probes for immunocyte activation and cellular cooperation, Transplant. Rev. 11:131.PubMedGoogle Scholar
  2. Baroni, C. D., Ruco, L., Soravito De Franceschi, S., Uccini, S., Adorini, L., and Doria, G., 1976, Biological effects of Escherichia coli lipopolysaccharide (LPS) in vivo. I. Selection in the mouse thymus of killer and helper cells, Immunology 31:217.PubMedGoogle Scholar
  3. Beller, D. I., Farr, A. G., and Unanue, E. R., 1978, Regulation of lymphocyte proliferation and differentiation by macrophages, Fed. Proc. 37:91.PubMedGoogle Scholar
  4. Cantor, H., and Gershon, R. K., 1979, Immunological circuits: Cellular composition, Fed. Proc. 38:2058.PubMedGoogle Scholar
  5. Chedid, L., 1973, Possible role of endotoxemia during immunologic imbalance, in: Bacterial Lipopolysaccharides (E. H. Kass and S. M. Wolff, eds.), pp. 104–109, University of Chicago Press, Chicago.Google Scholar
  6. Damais, C., Lamensans, A., and Chedid, L., 1972, Endotoxins bacteriennes et maladie homologue du nouveau-né, C. R. Acad. Sci. 274:1113.Google Scholar
  7. Dumont, F., 1978, Bacterial lipopolysaccharide (LPS) enhances concanavalin A reactivity of thymocytes from the low-LPS-responder mouse strain C3H/HeJ, Expenentia 34: 125.CrossRefGoogle Scholar
  8. Fox, M., 1966, Lymphoid repopulation by donor cells in the graft-versus-host reaction, Transplantation 4:11.CrossRefGoogle Scholar
  9. Franzi, R. E., and McMaster, P. D., 1968, The primary immune response in mice. I. The enhancement and suppression of hemolysin production by a bacterial endotoxin, J.Exp. Med. 127:1087.CrossRefGoogle Scholar
  10. Gery, I., Gershon, R. K., and Waksman, B. H., 1971, Potentiation of cultured mouse thymocyte responses by factors released by peripheral leucocytes,J.Immunol. 107:1778.PubMedGoogle Scholar
  11. Gery, I., Gerson, R. K., and Waksman, B. H., 1972a, Potentiation of the T-lymphocyte response to mitogens. I. The responding cell,J.Exp. Med. 136:128.PubMedCrossRefGoogle Scholar
  12. Gery, I., Kruger, J., and Spiesel, S. Z., 1972b, Stimulation of B-lymphocytes by endotoxin: Reactions of thymus-deprived mice and karyotypic analysis of dividing cells in mice bearing T6-T6 thymus grafts,J.Immunol. 108:1088.PubMedGoogle Scholar
  13. Grebe, S. C., and Streilein, J. W., 1976, Graft-versus-host reactions: A review, Adv. Immunol. 22:119.PubMedCrossRefGoogle Scholar
  14. Gronowicz, E., and Coutinho, A., 1974, Selective triggering of B cell subpopulations by mitogens, Eur. J. Immunol. 4:771.PubMedCrossRefGoogle Scholar
  15. Gronowicz, E., and Coutinho, A., 1975, Functional analysis of B cell heterogeneity, Transplant. Rev. 24:3.PubMedGoogle Scholar
  16. Haas, G. P., Johnson, A. G., and Nowotny, A., 1978, Suppression of the immune response in C3H JHeJ mice by protein-free lipopolysaccharides,JExp. Med. 148:1081.CrossRefGoogle Scholar
  17. Liacopoulos, M., Lambert, F., and Liacopoulos, P., 1980, Nonspecific inhibitory processes of immunological and mitogenic cellular responses. I. Comparative effect of four suppressive agents, Immunology 41:143.PubMedGoogle Scholar
  18. Liacopoulos, P., and Merchant, B., 1969, Effet du traitement des donneurs avec des endotoxines sur la maladie homologue des receveurs adultes irradiés, in: La structure et les effets biologiques des produits bactériens provenants de germes Gram-négatifs (L. Chedid, ed.), pp. 341–356, Colloq. Int. sur les Endotoxines, CNRS No. 174, Paris.Google Scholar
  19. Liacopoulos, P., Merchant, B., and Harrel, B. E., 1967a, Effect of donor immunization with somatic polysaccharides on the graft-versus-host reactivity of transferred donor splenocytes, Proc. Soc. Exp. Biol. Med. 125:958.PubMedGoogle Scholar
  20. Liacopoulos, P., Merchant, B., and Harrel, B. E., 1967b, Inhibition of the graft-versus-host reaction by pretreatment of donors with various antigens, Transplantation 5:1423.CrossRefGoogle Scholar
  21. Liacopoulos, P., Herlem, G., and Perramant, M. F., 1968, Suppression de la maladie homologue et induction de tolerance dans une combinaison de souris adultes de locus H2 different, in: Advances in Transplantation (J. Dausset, J. Hamburger, and G. Mathe, eds.), p. 183–187, Munksgaard, Copenhagen.Google Scholar
  22. McMaster, P. D., and Franzi, R. E., 1968, The primary immune response in mice. II. Cellular responses of lymphoid tissue accompanying the enhancement or complete suppression of antibody formation by a bacterial endotoxin,J.Exp. Med. 127:1109.PubMedCrossRefGoogle Scholar
  23. Meltzer, M., and Oppenheim, J. J., 1977, Bidirectional amplification of macrophage-lymphocyte interactions: Enhanced lymphocyte activation factor production by activated adherent mouse peritoneal cells,J.Immunol. 118:77.PubMedGoogle Scholar
  24. Mizel, S. B., Oppenheim, J. J., and Rosenstreich, D. L., 1978, Characterization of lymphocyte-activating factor (LAF) produced by a macrophage cell line, P388D, J. Immunol. 120:1504.PubMedGoogle Scholar
  25. Möller, G., Andersson, J., and Sjöberg, O., 1972, Lipopolysaccharide can convert heterologous erythrocytes into thymus-independent antigens, Cell. Immunol. 4:416.PubMedCrossRefGoogle Scholar
  26. Morrison, D. C., and Ryan, J. L., 1979, Bacterial endotoxins and host immune responses, Adv. Immunol. 28:293.PubMedCrossRefGoogle Scholar
  27. Murphy, D. B., 1978, The I. J. subregion of the murine H2 gene complex, Springer Semin. Immunopathol. 1:111.CrossRefGoogle Scholar
  28. Nowotny, A., 1963, Endotoxoid preparations, Nature (London) 197:721.CrossRefGoogle Scholar
  29. Ozato, K., Adler, W. H., and Ebert, J. D., 1975, Synergism of bacterial lipopolysaccha-rides and concanavalin A in the activation of thymic lymphocytes, Cell. Immunol. 17: 532.PubMedCrossRefGoogle Scholar
  30. Persson, U., 1977, Lipopolysaccharide-induced suppression of the primary immune response to a thymus-dependent antigen,J. Immunol. 118:789.PubMedGoogle Scholar
  31. Ptak, W., Zembala, M., and Gershon, R. K., 1978, Intermediary role of macrophages in the passage of suppressor signals between T-cell subsets,JExp. Med. 148:424.CrossRefGoogle Scholar
  32. Simonsen, M., 1962, Graft versus host reactions: Their natural history and applicability as tools of research, Prog. Allergy 6:349.PubMedGoogle Scholar
  33. Sjöberg, O., Andersson, J., and Möller, G., 1972, Lipopolysaccharide can substitute for helper cells in the antibody response in vitro, Eur. J. Immunol. 2:326.PubMedCrossRefGoogle Scholar
  34. Skopinska, E., 1972, Some effects of Escherichia coll endotoxin on the graft-versus-host reaction in mice, Transplantation 14:432.PubMedCrossRefGoogle Scholar
  35. Thomson, P. D., and Jutila, J. W., 1974, The suppression of graft-versus-host disease in mice by endotoxin-treatcd adherent spleen cells,J. Reticuloendothelial Soc. 16:327.Google Scholar
  36. Thomson, P. D., Rampy, P. A., and Jutila, J. W., 1978, A mechanism for the suppression of graft-versus-host disease with endotoxin,J. Immunol. 120:1340.PubMedGoogle Scholar
  37. Uchiyama, T., and Jacobs, D. M., 1978a, Modulation of immune response by bacterial lipopolysaccharide (LPS): Multifocal effects of LPS induced suppression on the primary antibody response to a T-dependent antigen,J. Immunol. 121:2340.PubMedGoogle Scholar
  38. Uchiyama, T., and Jacobs, D. M., 1978b, Modulation of immune response by bacterial lipopolysaccharide (LPS): Cellular basis of stimulatory and inhibitory effects of LPS on the in vitro IgM antibody response to a T-dependent antigen, Jimmunol. 121: 2347.PubMedGoogle Scholar
  39. Villeneuve, L., Brousseau, P., Chaput, J., and Elie, R., 1980 Role of the adherent cells in graft-versus-host induced suppression of the humoral immune response, Scand. J. Immunol. 12:321.PubMedCrossRefGoogle Scholar
  40. Wolters, E. A. J., and Benner, R., 1980, Different target antigens for T-cell subsets acting synergistically in vivo, Nature, (London) 286:895.CrossRefGoogle Scholar
  41. Yamashita, A., Hattori, Y., and Fukumoto, T., 1980, Augmenting effect of exogenous macrophages on the rat graft-versus-host reaction in F, hybrids depleted of macrophages, Transplantation 30:122.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • P. Liacopoulos
    • 1
  1. 1.Institut d’Immunobiologie (INSERM U.20, CNRS, L.A. 143)Hôpital BroussaisParis Cedex 14France

Personalised recommendations