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Beneficial Effects of Endotoxins pp 397–413Cite as

Endotoxin-Induced Release of Colony-Stimulating Factor

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Abstract

The introduction of an in vitro technique for cloning granulocyte and macrophage precursor cells by Pluznik and Sachs (1965) and Bradley and Metcalf (1966) provided a new approach to the evaluation of the regulation of granulopoiesis and macrophage formation. Committed precursor cells for granulocyte and macrophage differentiation can proliferate in soft agar cultures to form colonies of granulocytes and/or macrophages (Ichikawa et al., 1966). Colonies arise from single cells termed colony-forming cells (CFC) (Pluznik and Sachs, 1966). Colony formation is wholly dependent upon the constant presence of a stimulatory glycoprotein substance named colony-stimulating factor (CSF).

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Author information

Author notes

  1. Dov H. Pluznik

    Present address: Laboratory of Microbiology and Immunology, National Institute of Dental Research, NIH, Bethesda, Maryland, 20205, USA

Authors and Affiliations

  1. Department of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel

    Dov H. Pluznik

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  1. Dov H. Pluznik
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Editors and Affiliations

  1. Center for Oral Health Research, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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© 1983 Plenum Press, New York

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Pluznik, D.H. (1983). Endotoxin-Induced Release of Colony-Stimulating Factor. In: Nowotny, A. (eds) Beneficial Effects of Endotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4364-6_20

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  • DOI: https://doi.org/10.1007/978-1-4684-4364-6_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4366-0

  • Online ISBN: 978-1-4684-4364-6

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