Induction of Interferon by Endotoxin

  • Monto Ho

Abstract

The ability of bacterial endotoxin to modify virus infections was well documented before it was found it could induce interferon. Endotoxin decreased both the toxicity and the replication of some viruses. Hook and Wagner (1959) found that as little as 0.008 μg of purified E. coli lipopolysaccharide (LPS) inoculated intracerebrally in mice 75 min to 31/2 hr before an intracerebral challenge of 3–8 LD50 of WS influenza virus decreased the direct neurotoxic effects of this virus. Typhoid vaccine was similarly effective. This protective effect lasted for about 7 days. No effect on viral multiplication in the brain was found.

Keywords

Influenza Cortisol Tuberculosis Bacillus Trypsin 

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Monto Ho
    • 1
    • 2
  1. 1.Department of MicrobiologyGraduate School of Public HealthPittsburghUSA
  2. 2.Department of Medicine, School of MedicineUniversity of PittsburghPittsburghUSA

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