The Role of Humoral Factors in Endotoxin-Induced Reactions

  • L. Joe Berry
  • Jeanne E. Gaska


Within the last half-decade it has become abundantly clear that many of the biological effects of bacterial endotoxin are mediated by what is believed to be a number of different protein and glycoprotein molecules (Berry, 1977; Moore and Berry, 1982). These molecules are derived from cells of the reticuloendothelial system (RES), especially macrophages but from other cells as well. It is intriguing to realize that a diffuse tissue such as the RES qualifies functionally as part of the endocrine system and the mediators as hormones. There is no anatomical or physiological reason why this should not be true since chromaffin tissue, a source of epinephrine and norephinephrine, is also diffusely distributed.


Colony Stimulate Factor Humoral Factor Bacterial Endotoxin Peritoneal Exudate Cell Mouse Spleen Cell 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • L. Joe Berry
    • 1
  • Jeanne E. Gaska
    • 1
  1. 1.Department of MicrobiologyUniversity of TexasAustinUSA

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