In Vitro Adjuvant Effect of Endotoxin

Review and Experiments
  • Masayasu Nakano
  • Takehiko Uchiyama


Mishell and Dutton (1967) devised a method that initiates an immune response in cultures of free spleen cells from unimmunized mice. This method allows the investigation of biochemical and cellular events associated with induction and development of the immune response and enables the investigator to use an intrinsically simpler system for analysis than is true when intact animals are employed.


Bone Marrow Cell Spleen Cell Adjuvant Effect Adjuvant Action Bone Marrow Cell Culture 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Masayasu Nakano
    • 1
  • Takehiko Uchiyama
    • 2
  1. 1.Department of MicrobiologyJichi Medical SchoolTochigiJapan
  2. 2.Department of MicrobiologyKitasato University School of MedicineKanagawa 228Japan

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