Adjuvant Action of Bacterial Endotoxins on Antibody Formation

A Historical Perspective
  • Arthur G. Johnson


One of the most dramatic of the potentially beneficial actions of the endotoxins derived from gram-negative bacteria has been their capacity to elevate antibody levels to unrelated antigens in animals. This truly profound effect of the isolated lipopolysaccharide component (LPS) has been known for over 25 years (Johnson et al., 1956), and has found application in many experimental immunology laboratories throughout the world.


Typhoid Fever Serratia Marcescens Antibody Formation Pertussis Vaccine Bacterial Endotoxin 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Arthur G. Johnson
    • 1
  1. 1.Department of Medical Microbiology/ImmunologyUniversity of MinnesotaDuluthMinnesotaUSA

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