Lymphocyte Activation by Endotoxin and Endotoxin Protein

The Role of the C3H/HeJ Mouse
  • Barnet M. Sultzer


A perusal of the literature on endotoxins in the past decade makes it clear that a renewed interest has developed to explain the multiple pathophysiological and immunological host responses to lipopolysac-charide endotoxin (LPS). In great measure this was due to the recognition that many of these responses were under genetic control. The genetic approach taken by numerous workers arose from the discovery of the mutant C3H/HeJ mouse strain, which is highly resistant to the toxic effects of LPS and which displays cellular responses both in vivo and in vitro that are diametrically opposite to those from normally susceptible mice (Sultzer, 1968, 1969). The availability of this inbred strain gave rise to a variety of comparative studies so that a rather extensive literature on this subject has accumulated and continues to do so. However, within the allotted space for this article, I will only attempt to highlight those aspects of the work with this strain that have dealt with the activation of lymphocytes by LPS, and to discuss in some detail the newer studies originating from the use of the C3H/HeJ mouse that have established that various proteins associated with the LPS in the outer membrane of gram-negative bacteria are potent activators of immunocompetent cells.


Spleen Cell Migration Inhibition Factor Lymphocyte Activation Splenic Lymphocyte Human Peripheral Blood Lymphocyte 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Barnet M. Sultzer
    • 1
  1. 1.Department of Microbiology and ImmunologyState University of New York Downstate Medical CenterBrooklynUSA

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