Stimulation of Nonspecific Resistance by Radiation-Detoxified Endotoxin

  • Lóránd Bertók


Many years ago, some investigators observed that within 24 hr of intravenous inoculation with killed typhoid bacilli, animals developed increased resistance to the live culture. Later, other workers identified the endotoxic lipopolysaccharides as the active material in such vaccines. The effects of this LPS-induced enhanced resistance have been demonstrated in infections induced by parasites, fungi, viruses, grampositive and gram-negative bacteria, and mycobacteria. It is also well known that repeated parenteral injections of small doses of LPS will produce endotoxin tolerance. Among the several factors that may be involved in inducing this tolerance, bacterial LPS seems to play the major role in stimulating the host’s natural defenses (Milner et al., 1971; Pusztai-Markos, 1975). This tolerance has been manifested in an immunologically nonspecific manner, where endotoxic shock could be prevented by previous applications of small doses of endotoxin or endotoxin derivatives.


Superior Mesenteric Artery Hemorrhagic Shock Bacterial Endotoxin Endotoxic Shock Fecal Peritonitis 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Lóránd Bertók
    • 1
  1. 1.“Frèdèric Joliot-Curie” National Research Institute for Radiobiology and RadiohygieneBudapestHungary

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