In Search of the Active Sites in Endotoxins

  • A. Nowotny


The history of fever, studies of its effects and search for its origin, go back as far as the history of medicine. The beneficial effects of fever were praised by famous healers in Egypt, Greece, and in the Roman and Persian empires several millenia ago. This appreciation continued through the Middle Ages into our modern times, when “fever therapy” was applied to diseases as diverse as rheumatoid arthritis (Barsi, 1947), manic depression (Terry, 1939), headaches (Sutherland and Wolf, 1940), neurosyphilis (Favorite and Morgan, 1946), herpes zoster (Bernstein and Klotz, 1947), various eye and skin diseases (Tucker, 1946), and many others.


Serratia Marcescens Bacterial Endotoxin Lipid Moiety Mouse Spleen Cell Shigella Sonnei 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • A. Nowotny
    • 1
  1. 1.Center for Oral Health Research, School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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