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The Nature of Muscarinic Receptor Binding

  • Frederick J. Ehlert
  • William R. Roeske
  • Henry I. Yamamura
Part of the Handbook of Psychopharmacology book series (HBKPS)

Abstract

During the last decade, the availability of muscarinic cholinergic drugs of high specific activity has enabled a direct characterization of the way in which acetylcholine and other drugs interact with the muscarinic receptor. As might be anticipated, the advent of a new experimental method of scientific inquiry is often followed by a surge of information, and such is the relationship between the development of receptor binding techniques and muscarinic receptor Pharmacology. In general, the recent knowledge derived from studies of the binding of muscarinic agonists and antagonists is consistent with classical theories of agonist-receptor interaction and competitive inhibition which were developed primarily from studies of the interaction of drugs with isolated smooth muscle preparations such as the guinea pig ileum. However, additional complicated ligand-receptor interactions have been detected by receptor binding methods which could not have been realized from the results of classical Pharmacological assays on whole tissue preparations.

Keywords

Adenylate Cyclase Muscarinic Receptor Longitudinal Muscle Guanine Nucleotide Corpus Striatum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Frederick J. Ehlert
    • 1
    • 2
    • 3
    • 4
  • William R. Roeske
    • 1
    • 2
    • 3
    • 4
  • Henry I. Yamamura
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of PharmacologyUniversity of Arizona Health Sciences CenterTucsonUSA
  2. 2.Department of PsychiatryUniversity of Arizona Health Sciences CenterTucsonUSA
  3. 3.Department of BiochemistryUniversity of Arizona Health Sciences CenterTucsonUSA
  4. 4.Department of Internal MedicineUniversity of Arizona Health Sciences CenterTucsonUSA

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