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Opiate Receptors

  • Linda E. Robson
  • Stewart J. Paterson
  • Hans W. Kosterlitz
Part of the Handbook of Psychopharmacology book series (HBKPS)

Abstract

A fundamental concept of modern pharmacology is that the biological activity of a drug results from its interaction with a macromolecular tissue component. Such a receptor must be defined in terms of its pharmacology: it encompasses both a recognition site to which a drug binds, and a factor which translates binding into the events which lead ultimately to a biological response. A drug which binds specifically to the recognition site has an affinity for that receptor, usually expressed as the equilibrium dissociation constant K D, which is the ratio of the association and dissociation rate constants. Agonists have, in addition to affinity for the recognition site, the ability to trigger the translational phase to produce a biological effect, while antagonists fail to elicit a biological response. This chapter will deal primarily with the biochemical characterization of the opiate receptors. Since binding studies yield information only about the recognition site of the receptor, they cannot distinguish between the agonist or antagonist nature of the interactions. We shall therefore correlate the biochemical data with results from pharmacological assays.

Keywords

Opioid Peptide None None Opiate Receptor Unlabeled Ligand Toad Brain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Linda E. Robson
    • 1
  • Stewart J. Paterson
    • 1
  • Hans W. Kosterlitz
    • 1
  1. 1.Unit for Research on Addictive DrugsUniversity of Aberdeen, Marischal CollegeAberdeenScotland

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