Dose Response Relations: The Effects of DNA Repair
Environmental agents that react with DNA, either directly or indirectly by conversion to reactive intermediates, are potentially harmful to people. The biological effects of concern are cell killing, mutation, and transformation. The magnitude of the potential danger to humans from changes in their DNA depends upon the types of changes made and their lifetimes relative to the times of important cellular processes, such as replication, transcription, and cell division. It should be obvious that we cannot wait for epidemiological data to assess the hazards or the safety of agents that affect DNA. If we did, the harm would have been done and perpetuated before any corrective action could be taken.
KeywordsAtaxia Telangiectasia Xeroderma Pigmentosum Ataxia Telangiectasia Dose Response Relation Pyrimidine Dimer
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