Study of Pesticide Genotoxicity

  • Michael D. Waters
  • Shahbeg S. Sandhu
  • Vincent F. Simmon
  • Kristien E. Mortelmans
  • Ann D. Mitchell
  • Ted A. Jorgenson
  • David C. L. Jones
  • Ruby Valencia
  • Neil E. Garrett
Part of the Basic Life Sciences book series (volume 6)


With a limited supply of arable land supporting an ever-increasing human population, the threat of crop loss to agricultural pests becomes continually more acute. Thus pesticides have become an essential component of modern agriculture. As competing organisms evolve resistance to commonly used agents, new and more effective poisons and repellants must constantly be developed. The fundamental problem in pesticide development is to produce chemicals that act specifically against certain organisms without adversely affecting others. Because of the similarities in the structural, metabolic and genetic components of all life forms, absolute species specificity is frequently difficult to attain. Furthermore, such toxic chemicals improperly used may engender biological effects beyond those for which they were originally manufactured.


Genotoxic Effect Eukaryotic System Genetic Activity Chromosomal Effect Initial Battery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Michael D. Waters
    • 1
  • Shahbeg S. Sandhu
    • 1
  • Vincent F. Simmon
    • 2
  • Kristien E. Mortelmans
    • 2
  • Ann D. Mitchell
    • 2
  • Ted A. Jorgenson
    • 2
  • David C. L. Jones
    • 2
  • Ruby Valencia
    • 3
  • Neil E. Garrett
    • 4
  1. 1.Genetic Toxicology DivisionU.S. Environmental Protection AgencyUSA
  2. 2.SRI InternationalMenlo ParkUSA
  3. 3.WARF Institute, Inc.MadisonUSA
  4. 4.Northrop Services, Inc.USA

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