Cytology of the Prostate
As early as 1930 Ferguson described a method of needle puncture and aspiration of the prostate for diagnostic purposes (1). From his work mainly originated the so-called thick needle biopsy for which several instruments were designed. The best known are the Vim-Silverman needle, the Veenema needle and that most commonly used now, the Tru-cut needle. All give punch-biopsies which can be used for histological examination as well as for histochemical reactions (acid phosphatase, peroxidase, etc.). For several decades this was the recognized method for pathological diagnosis of prostatic carcinoma, the diagnosis being based mainly on the structure and architecture of the malignant epithelial cells in relation to the stroma and on some cytologic criteria.
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