Hormone Therapy and Receptor Studies in Human Renal Cell Carcinoma
There is very clear experimental evidence of the hormone-dependence of renal cancer in the male hamster (1–5) but little evidence of the effectiveness of hormone therapy in humans. Opinions are controversial and Hrushesky & Murphy (6) pointed out that the cumulative reported response rate to either progesterone or androgen therapy in advanced renal cell carcinoma was 17% in the literature up to 1971 and less than 2% afterwards. In recent years, antiestro-gens have been tried and the response rate reported in the largest published series (7) is 4% objective remission and 28% subjective improvement. Different criteria of evaluation may be responsible for the widely differing results reported in the older literature.
KeywordsRenal Cell Carcinoma Renal Cancer Renal Carcinoma Syrian Hamster Neoplastic Tissue
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